| Issue | Title | |
| No 2 (2024) | “Holiday heart” syndrome in rats: Features of microcirculation, functional state and anatomy of the heart | Abstract PDF (Rus) |
| S. A. Kryzhanovskii, I. B. Tsorin, E. O. Ionova, M. B. Vititnova, S. A. Simonenko, L. G. Kolik | ||
| No 4 (2023) | In-vitro dissolution profiles comparison for various drugs with active ingredient Febuxostat commercially available on the Russian market | Abstract PDF (Rus) |
| S. V. Denkina, M. Y. Gadaev, D. Yu. Grebenkin, A. V. Ryabova, I. V. Kislyakov | ||
| No 1 (2014) | 10th anniversary of the journal «Pharmacokinetics and pharmacodynamics» | Abstract PDF (Rus) |
| V. P. Zherdev | ||
| No 4 (2024) | 2-[3-(2-chloroethyl)-3-nitrosoureido]-1,3-propanediol (chlonisol): blood content in rats after intravenous administration and chemical resistance | Abstract PDF (Rus) |
| V. A. Alexandrov, G. V. Tochilnikov, S. V. Shatik, A. N. Stukov, O. A. Beljaeva, E. V. Bashkatova, V. G. Dranishnikov, T. Yu. Semiglazova | ||
| No 1 (2015) | A comparative study of pharmacokinetics and bioequivalence of Cardiopril tablets 20 mg (JSC «Himfarm», Kazakhstan) and Monopril® tablets of 20 mg («Bristol-Myers Squibb SRL», Italy) | Abstract PDF (Rus) |
| A. K. Sariev, D. A. Abaimov, M. V. Tankevich, S. A. Altinbekov, G. A. Dzholdygulov, V. N. Seryakov, Y. . Budach, O. . Kurilov | ||
| No 4 (2016) | A comparative study of pharmacokinetics of coated tablets of mycophenolic acid | Abstract PDF (Rus) |
| A. L. Khokhlov, I. I. Yaichkov, A. M. Shitova, L. N. Shitov, Yu. A. Dzhurko, A. E. Miroshnikov | ||
| No 2 (2019) | A comparative study of the anti-ischemic activity of trimetazidine and the compound ALM-802 under conditions of endothelial dysfunction | Abstract PDF (Rus) |
| V. V. Barchukov, I. B. Tsorin, A. M. Likhosherstov, M. B. Vititnova, G. V. Mokrov, S. A. Kryzhanovskii | ||
| No 1 (2025) | A promising biological model of gestational diabetes mellitus with specific impairments of carbohydrate and lipid metabolism in rats | Abstract PDF (Rus) |
| K. S. Kachalov, A. S. Solomina, A. V. Rodina, A. D. Durnev | ||
| No 3 (2017) | A study of neuroprotective effect stereospecificity of dipeptide mimetic of the Brain-derived neurotrophic factor GSB-106 on the model oxidative stress in the culture hippocampal cell line HT-22 | Abstract PDF (Rus) |
| I. O. Logvinov, A. V. Tarasiuk, P. I. Antipov, T. A. Antipova | ||
| No 1 (2024) | A study on the mnemotropic and antidepressant-like effects of the low-molecular-weight mimetic of nerve growth factor, dipeptide GK-2, in experimental ischemic stroke | Abstract PDF (Rus) |
| P. Yu. Povarnina, N. M. Sazonova, D. M. Nikiforov, T. A. Gudasheva, V. L. Dorofeev | ||
| No 2 (2020) | About interrelations between levels of a neurotrophic factor of a brain in blood, microelements in hair at young age | Abstract PDF (Rus) |
| E. G. Pepelyaev, V. A. Semenov, I Yu. Torshin, O. A. Gromova | ||
| No 2 (2021) | Absolute bioavailability of a substance with cardioprotective activity (ALM-802) in rats | Abstract PDF (Rus) |
| G. B. Kolyvanov, P. O. Bochkov, A. A. Litvin, R. V. Shevchenko, A. L. Podolko, V. P. Zherdev | ||
| No 3 (2022) | Activity of 2-[3-(2-chloroethyl)-3-nitrosoureido]-1,3-propandyоl (chlonisol) versus lomustine in intracranial transplanted tumor model in mice | Abstract PDF (Rus) |
| Yu. G. Zmitrichenko, A. N. Stukov, V. А. Aleksandrov, G. V. Tochilnikov, I. G. Murazov, D. Н. Latipova, L. V. Filatova, T. Yu. Semiglazova | ||
| No 4 (2023) | Acute toxicity study of a new dibenzofuran oxime derivative GIZH-272 in mice | Abstract PDF (Rus) |
| S. V. Alekseeva, A. V. Sorokina, A. V. . Volkova, I. A. Miroshkina, K. S. Kachalov, I. V. Alekseev, A. D. Zakharov, A. D. Durnev | ||
| No 3 (2018) | Afobazole inhibits ethanol-induced behavioral sensitization in DBA/2 mice | Abstract PDF (Rus) |
| A. V. Nadorova, L. G. Kolik | ||
| No 3 (2018) | Afobazole metabolite M-11 inhibits quinone reductase 2 | Abstract PDF (Rus) |
| I. A. Kadnikov, M. V. Voronin, S. B. Seredenin | ||
| No 3 (2018) | Afobazole prevents motor function impairment in mice with 6-OHDA induced Parkinsonism | Abstract PDF (Rus) |
| I. A. Kadnikov, M. V. Voronin, S. B. Seredenin | ||
| No 2 (2021) | An approach to the quantitative determination of endogenous substances in biological fluids by a chromatographic method using a mathematical apparatus | Abstract PDF (Rus) |
| V. V. Smirnov, L. M. Krasnykh, G. V. Ramenskaya, S. B. Kazanbekov | ||
| No 2 (2020) | An experimental study of the systemic bioavailability of the drug "Harmin hydrochloride, capsules" in comparison with native garmin on chinchilla rabbits | Abstract PDF (Rus) |
| S. M. Adekenov, V. S. Schnaukshta, E. V. Epifantseva, D. A. Abaimov, M. G. Abdrakhmanova, A. K. Sariev | ||
| No 1 (2024) | Analysis of original bis-arylazaazkanes derivatives compliance with the calculated pharmacophoric models of biaromatic ligands of cardioprotective drugs biotargets | Abstract PDF (Rus) |
| G. V. Mokrov, A. S. Pantileev, T. Yu. Vorobieva, V. E. Biryukova, S. A. Kryzhanovskii, V. L. Dorofeev | ||
| No 2 (2020) | Analysis of sparse data in pharmacokinetic studies | Abstract PDF (Rus) |
| I. I. Miroshnichenko, A. N. Simonov, I. I. Kuzmin, A. I. Platova | ||
| No 4 (2016) | Analysis of the light peptide fraction of Laennec by proteomic methods | Abstract PDF (Rus) |
| I. Yu. Torshin, V. G. Zgoda, O. A. Gromova, I. I. Baranov, V. I. Demidov, O. A. Nazarenko, N. Yu. Sotnikova, I. M. Karimova | ||
| No 3 (2017) | Animal models of depression | Abstract PDF (Rus) |
| T. L. Garibova, V. A. Kraineva, T. A. Voronina | ||
| No 4 (2018) | Antarite - synergistic combination of «magaldrat + simethicone» with gastroprotective properties | Abstract PDF (Rus) |
| I. Yu. Torshin, O. A. Gromova, N. A. Kuricina | ||
| No 2 (2021) | Antiarrhythmic properties of N-Deacetyllappaconitine Hydrochloride | Abstract PDF (Rus) |
| S. A. Kryzhanovskii, M. S. Yunusov, I. B. Tsorin, V. V. Barchukov, E. I. Barchukova | ||
| No 3 (2024) | Anticancer activity of tyrosine kinase TrkA receptors antagonist GK-1 in experiment on mice with mammary gland adenocarcinoma Ca755 | Abstract PDF (Rus) |
| L. P. Kovalenko, P. Yu. Povarnina, R. V. Zhurikov, S. V. Alekseeva, L. G. Kolik, T. A. Gudasheva, A. D. Durnev, V. I. Dorofeev | ||
| No 2 (2016) | Anticonvulsant effect of the derived 4-benzoylpyridine (giz-298) on paroxysmal activity in the brain structures of rats with cobalt-induced focal epilepsy in the first stage of the formation of epileptic system | Abstract PDF (Rus) |
| T. A. Voronina, O. I. Gaidukov, S. A. Litvinova, L. N. Nerobkova, L. A. Gmurenko | ||
| No 3 (2023) | Antidepressant activity of the pyrrolo[1,2a][1,4]diazepine GMAL-24 in a forced swimming test in mice | Abstract PDF (Rus) |
| A. O. Korolev, A. V. Volkova, Ya. S. Kozin, G. V. Mokrov, T. A. Voronina, T. S. Kalinina | ||
| No 4 (2019) | Antidepressant-like activity of the dipeptide mimetic of brain-derived neurotrophic factor GSB-106 in Porsolt test after intraperitoneal sub-chronically and chronically treatment in mice | Abstract PDF (Rus) |
| A. V. Tallerova, P. Y. Povarnina, S. V. Minaev, T. A. Gudasheva, S. B. Seredenin | ||
| No 3 (2022) | Anti-inflammatory properties of 5-hydroxypirimidine derivatives on the model of CFA-induced paw and ankle joint edema in rats | Abstract PDF (Rus) |
| R. V. Zhurikov, L. P. Kovalenko, S. V. Nikitin | ||
| No 2 (2018) | Antiischemic properties of the Trka-receptor agonist, the nerve growth factor 4-th loop mimetic | Abstract PDF (Rus) |
| E. S. Pekeldina, E. O. Ionova, I. A. Mirochkina, A. V. Sorokina, V. N. Stolyaruk, I. B. Tsorin, T. A. Gudacheva, S. A. Kryzhanovskii | ||
| No 2 (2019) | Antioxidant and anti-stress effect of ascorbate lithium has swine in biomedical model | Abstract PDF (Rus) |
| K. S. Ostrenko | ||
| No 1 (2022) | Application of the AlphaScreen and AlphaLisa method in drug development and pharmacokinetic studies | Abstract PDF (Rus) |
| R. T. Mukhametshina, S. D. Kopein, V. M. Simonov | ||
| No 1 (2023) | Application of variance analysis in experimental pharmacology | Abstract PDF (Rus) |
| I. B. Tsorin | ||
| No 1 (2019) | Approaches to predict ligands affinity towards translocator protein TSPO 18 kDa in order to create molecules possessing neuropsychotropic activity | Abstract PDF (Rus) |
| N. M. Baraboshkin, A. S. Pantileev, G. V. Mokrov | ||
| No 1 (2016) | Aspects of «Cocktail» cytochrome P450 activity determination methods application with the view of drug treatment rationalization | Abstract PDF (Rus) |
| E. . Egorenkov, V. . Smirnov, A. . Litvin, G. . Kolyvanov, G. . Ramenskaya | ||
| No 1 (2018) | Assessment of bioavailability of ethylthiadiazolylamide of acetylaminohexanoic acid by intragastric administration in rabbits | Abstract PDF (Rus) |
| A. S. Malygin, N. S. Popov, M. A. Demidova, S. B. Marasanov | ||
| No 3 (2016) | Assessment of pharmacokinetics-pharmacodynamics relationship of tropoxine in rats | Abstract PDF (Rus) |
| V. P. Zherdev, G. B. Kolyvanov, A. A. Litvin, A. A. Novitskyi, T. S. Ganshina, A. A. Gorbunov, R. S. Mirzoyan | ||
| No 4 (2022) | Assessment of pharmacological safety of a new dipeptide mimetic of the 2nd loop of BDNF when co-administered with ethanol | Abstract PDF (Rus) |
| A. V. Nadorova, E. M. Grigorevskikh, A. V. Tarasiuk, N. M. Sazonova, L. G. Kolik | ||
| No 1 (2024) | Assessment of the influence of demographic and anthropometric indicators on the variability of pharmacokinetic parameters | Abstract PDF (Rus) |
| V. B. Vasilyuk, A. B. Verveda, M. V. Faraponova, G. I. Syraeva | ||
| No 2 (2020) | BDNF level role in formation of cognitive violations at middle-aged persons | Abstract PDF (Rus) |
| E. G. Pepelyaev, V. A. Semenov, O. A. Gromova | ||
| No 2 (2024) | Behavioral features of Wistar rats in models of autism spectrum disorders induced by prenatal or postnatal administration of sodium valproate | Abstract PDF (Rus) |
| E. V. Savinkova, I. G. Kapitsa, T. A. Voronina | ||
| No 4 (2017) | Belousov Yuri Borisovich | Abstract PDF (Rus) |
| Editorial Article | ||
| No 1 (2013) | Bioequivalence of bisoprolol, coated tablets 10 mg JSC «Chimpharm» Republic of Kazakhstan | Abstract PDF (Rus) |
| Y. M. Budach, O. E. Kurilo, A. K. Sariev, D. A. Abaimov, M. V. Shiryaev, E. Y. Styrova, S. A. Altynbekov, G. A. Dzholdygulov, V. N. Seryakov, K. S. Altynbekov | ||
| No 1 (2015) | Bioequivalence studies Nipezam retard tablets, 400 mg (JSC «Himfarm», Kazakhstan) and Finlepsin® 400 retard tablets 400 mg («Pliva Krakow, SA Pharmaceutical company», Poland) | Abstract PDF (Rus) |
| A. K. Sariev, D. A. Abaimov, M. V. Tankevich, Y. . Budach, O. . Kurilov, S. A. Altinbekov, G. A. Dzholdygulov, V. N. Seryakov, K. S. Altinbekov | ||
| No 2 (2013) | Bioequivalence study drug containing memantine | Abstract PDF (Rus) |
| A. A. Karlitskaya, L. M. Krasnyh, V. V. Smirnov, G. F. Vasilenko, N. I. Kuznetsova, V. G. Kukes | ||
| No 1 (2022) | Bioequivalence study of fixed-dose combination Losartan + amlodipine + rosuvastatin Sanofi in comparison with coadministered fixed- dose combination Lozap® AM and monocomponent drug Crestor® in healthy subjects | Abstract PDF (Rus) |
| A. L. Khokhlov, D. Yu. Grebenkin, E. K. Faeva, V. I. Kazey, A. A. Khokhlov, A. E. Miroshnikov, O. V. Lebedeva | ||
| No 1 (2015) | Bioequivalence study of ondansetron tablets by HPLC-MS | Abstract PDF (Rus) |
| E. S. Stepanova, M. V. Ovcharov, S. S. Barsegyan, S. M. Nikonova, V. V. Shilov, V. V. Chistyakov | ||
| No 1 (2013) | Bioequivalence study of tablet forms of risperidone, olanzapine and quetiapine in healthy volunteers | Abstract PDF (Rus) |
| V. V. Pisarev, M. M. Ulyashova, K. A. Vdovin, N. I. Tiseyko | ||
| No 3 (2019) | Biosimilar of biphasic human insulin: results of a double-blind, randomized, comparative, cross-sectional clinical study of pharmacokinetics | Abstract PDF (Rus) |
| Tatyana Karonova, Alexander Mayorov, Igor Makarenko, Ekaterina Koksharova, Olga Ilyinichna Avdeeva, Alena Andreeva, Roman Dray | ||
| No 1 (2015) | Biosimilars - drugs of the future | Abstract PDF (Rus) |
| E. A. Eltcova, G. V. Ramenskaya, E. A. Smolyarchuk, A. V. Bushmanova | ||
| No 2 (2024) | Blood microcirculation under conditions of a translational model of alcohol cardiomyopathy in rats | Abstract PDF (Rus) |
| S. A. Kryzhanovskii, I. B. Tsorin, E. O. Ionova, S. A. Simonenko, M. B. Vititnova | ||
| No 3 (2017) | Brain-derived neurotrophic factor and its low-molecular mimetics | Abstract PDF (Rus) |
| T. A. Gudasheva, A. V. Tarasiuk, P. Yu. Povarnina, S. B. Seredenin | ||
| No 2 (2019) | Cardioelectric field on the body surface during atrial depolarization in rats with alcoholic cardiomyopathy | Abstract PDF (Rus) |
| S. L. Smirnova, I. M. Roshchevskaya, I. B. Tsorin, V. N. Stolyaruk, M. B. Vititnova, L. G. Kolik, S. A. Kryzhanovskii | ||
| No 1 (2021) | Cardioprotective effects of compound ALM-802 on subendocardial ischemia models | Abstract PDF (Rus) |
| I. B. Tsorin, V. V. Barchukov, M. B. Vititnova, A. M. Likhosherstov, G. V. Mokrov, S. A. Kryzhanovskii | ||
| No 3 (2016) | Chemoreactome modeling the effects of anions of lithium salts ascorbate, nicotinate, hydroxybutyrate komenata and lithium carbonate | Abstract PDF (Rus) |
| I. Yu. Torshin, I. S. Sardaryan, O. A. Gromova, V. A. Rastashansky, L. E. Fedotova | ||
| No 1 (2017) | Clinical pharmacokinetics of а new original dipeptide anxiolytic GB-115 | Abstract PDF (Rus) |
| V. P. Zherdev, G. B. Kolyvanov, A. A. Litvin, V. V. Smirnov, L. G. Kolik, S. Yu. Raskin, N. Yu. Ivashkina, T. A. Gudasheva, S. B. Seredenin | ||
| No 2 (2023) | Combination of a high-carbohydrate diet and streptozotoc in for modeling type 2 diabetes in Wistar rats | Abstract PDF (Rus) |
| S. V. Ivanov, R. U. Ostrovskaya | ||
| No 2 (2023) | Combined effect of fabomotizol and the compound ALM-802 on atrial depolarization in a translational model of alcoholic cardiomyopathy in rats | Abstract PDF (Rus) |
| S. L. Smirnova, I. M. Roshchevskaya, V. V. Barchukov, I. B. Tsorin, S. A. Kryzhanovskii | ||
| No 3 (2020) | Combined oral contraception and treatment of new coronavirus infection (COVID-19): drug interaction issues | Abstract PDF (Rus) |
| O. A. Limanova, O. A. Gromova, L. E. Fedotova | ||
| No 2 (2016) | Comparative analysis activation of post-receptor signal ways by dimeric dipeptide mimetiks of different loops of NGF | Abstract PDF (Rus) |
| T. A. Antipova, I. O. Logvinov, S. V. Nikolaev, S. V. Kruglov, A. V. Tarasiuk, P. I. Antipov, T. A. Gudasheva, S. B. Seredenin | ||
| No 2 (2013) | Comparative bioequivalence study of Pioglitazone tablets, 20 mg (JSC «Chimpharm», Kazakhstan) and Actos® Tablets, 30 mg («Eli Lilly Holdings, Takeda Global Research and Development Centre Europe Ltd») | Abstract PDF (Rus) |
| A. K. Sariev, D. A. Abaimov, M. V. Shiryaev, E. Y. Styrova, S. A. Altynbekov, G. A. Dzholdygulov, V. N. Seryakov, Y. M. Budach, O. E. Kurilo | ||
| No 4 (2016) | Comparative chemoreactome analysis of mexidol | Abstract PDF (Rus) |
| I. J. Torshin, O. A. Gromova, I. S. Sardaryan, L. E. Fedotova, V. A. Semenov | ||
| No 2 (2021) | Comparative chemoreactomic analysis of ornithine aspartate, S-ademethionine and ursodeoxycholic acid | Abstract PDF (Rus) |
| I. Yu. Torshin, O. A. Gromova | ||
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Keywords
BDNF
GSB-106
NGF
acute toxicity
bioequivalence
chronic toxicity
echocardiography
mice
neuroprotection
oxidative stress
pharmacokinetics
preclinical pharmacokinetics
rabbits
rats
ВЭЖХ
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крысы
нейропротекция
терапевтический лекарственный мониторинг
фармакодинамика
фармакокинетика
Editorial address:
125315, Russian Federation, Moscow, st. Baltiyskaya, 8, FSBI "Federal Research Center for Original and Prospective Biomedical and Pharmaceutical Technologies"
Editor-in-Chief Vladimir Zherdev
Tel. +7 (495) 601-21-57; Email: zherdevpharm@mail.ru
Publisher address:
115522, Russian Federation, Moscow, Moskvorechye st., 4-5-129, Publishing House OKI, LLC
General Director Elena Afanasyeva
Tel. + 7 (916) 986-04-65; Email: eva88@list.ru
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