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Pharmacokinetics and Pharmacodynamics

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Issue Title
 
No 2 (2024) “Holiday heart” syndrome in rats: Features of microcirculation, functional state and anatomy of the heart Abstract   PDF (Rus)
S. A. Kryzhanovskii, I. B. Tsorin, E. O. Ionova, M. B. Vititnova, S. A. Simonenko, L. G. Kolik
 
No 4 (2023) In-vitro dissolution profiles comparison for various drugs with active ingredient Febuxostat commercially available on the Russian market Abstract   PDF (Rus)
S. V. Denkina, M. Y. Gadaev, D. Yu. Grebenkin, A. V. Ryabova, I. V. Kislyakov
 
No 1 (2014) 10th anniversary of the journal «Pharmacokinetics and pharmacodynamics» Abstract   PDF (Rus)
V. P. Zherdev
 
No 4 (2024) 2-[3-(2-chloroethyl)-3-nitrosoureido]-1,3-propanediol (chlonisol): blood content in rats after intravenous administration and chemical resistance Abstract   PDF (Rus)
V. A. Alexandrov, G. V. Tochilnikov, S. V. Shatik, A. N. Stukov, O. A. Beljaeva, E. V. Bashkatova, V. G. Dranishnikov, T. Yu. Semiglazova
 
No 1 (2015) A comparative study of pharmacokinetics and bioequivalence of Cardiopril tablets 20 mg (JSC «Himfarm», Kazakhstan) and Monopril® tablets of 20 mg («Bristol-Myers Squibb SRL», Italy) Abstract   PDF (Rus)
A. K. Sariev, D. A. Abaimov, M. V. Tankevich, S. A. Altinbekov, G. A. Dzholdygulov, V. N. Seryakov, Y. . Budach, O. . Kurilov
 
No 4 (2016) A comparative study of pharmacokinetics of coated tablets of mycophenolic acid Abstract   PDF (Rus)
A. L. Khokhlov, I. I. Yaichkov, A. M. Shitova, L. N. Shitov, Yu. A. Dzhurko, A. E. Miroshnikov
 
No 2 (2019) A comparative study of the anti-ischemic activity of trimetazidine and the compound ALM-802 under conditions of endothelial dysfunction Abstract   PDF (Rus)
V. V. Barchukov, I. B. Tsorin, A. M. Likhosherstov, M. B. Vititnova, G. V. Mokrov, S. A. Kryzhanovskii
 
No 1 (2025) A promising biological model of gestational diabetes mellitus with specific impairments of carbohydrate and lipid metabolism in rats Abstract   PDF (Rus)
K. S. Kachalov, A. S. Solomina, A. V. Rodina, A. D. Durnev
 
No 3 (2017) A study of neuroprotective effect stereospecificity of dipeptide mimetic of the Brain-derived neurotrophic factor GSB-106 on the model oxidative stress in the culture hippocampal cell line HT-22 Abstract   PDF (Rus)
I. O. Logvinov, A. V. Tarasiuk, P. I. Antipov, T. A. Antipova
 
No 1 (2024) A study on the mnemotropic and antidepressant-like effects of the low-molecular-weight mimetic of nerve growth factor, dipeptide GK-2, in experimental ischemic stroke Abstract   PDF (Rus)
P. Yu. Povarnina, N. M. Sazonova, D. M. Nikiforov, T. A. Gudasheva, V. L. Dorofeev
 
No 2 (2020) About interrelations between levels of a neurotrophic factor of a brain in blood, microelements in hair at young age Abstract   PDF (Rus)
E. G. Pepelyaev, V. A. Semenov, I Yu. Torshin, O. A. Gromova
 
No 2 (2021) Absolute bioavailability of a substance with cardioprotective activity (ALM-802) in rats Abstract   PDF (Rus)
G. B. Kolyvanov, P. O. Bochkov, A. A. Litvin, R. V. Shevchenko, A. L. Podolko, V. P. Zherdev
 
No 3 (2022) Activity of 2-[3-(2-chloroethyl)-3-nitrosoureido]-1,3-propandyоl (chlonisol) versus lomustine in intracranial transplanted tumor model in mice Abstract   PDF (Rus)
Yu. G. Zmitrichenko, A. N. Stukov, V. А. Aleksandrov, G. V. Tochilnikov, I. G. Murazov, D. Н. Latipova, L. V. Filatova, T. Yu. Semiglazova
 
No 4 (2023) Acute toxicity study of a new dibenzofuran oxime derivative GIZH-272 in mice Abstract   PDF (Rus)
S. V. Alekseeva, A. V. Sorokina, A. V. . Volkova, I. A. Miroshkina, K. S. Kachalov, I. V. Alekseev, A. D. Zakharov, A. D. Durnev
 
No 3 (2018) Afobazole inhibits ethanol-induced behavioral sensitization in DBA/2 mice Abstract   PDF (Rus)
A. V. Nadorova, L. G. Kolik
 
No 3 (2018) Afobazole metabolite M-11 inhibits quinone reductase 2 Abstract   PDF (Rus)
I. A. Kadnikov, M. V. Voronin, S. B. Seredenin
 
No 3 (2018) Afobazole prevents motor function impairment in mice with 6-OHDA induced Parkinsonism Abstract   PDF (Rus)
I. A. Kadnikov, M. V. Voronin, S. B. Seredenin
 
No 3 (2025) Alternative model Danio rerio for screening evaluation of thermoand frigoprotective action of pharmacological compounds Abstract   PDF (Rus)
A. O. Revyakin
 
No 2 (2021) An approach to the quantitative determination of endogenous substances in biological fluids by a chromatographic method using a mathematical apparatus Abstract   PDF (Rus)
V. V. Smirnov, L. M. Krasnykh, G. V. Ramenskaya, S. B. Kazanbekov
 
No 2 (2020) An experimental study of the systemic bioavailability of the drug "Harmin hydrochloride, capsules" in comparison with native garmin on chinchilla rabbits Abstract   PDF (Rus)
S. M. Adekenov, V. S. Schnaukshta, E. V. Epifantseva, D. A. Abaimov, M. G. Abdrakhmanova, A. K. Sariev
 
No 1 (2024) Analysis of original bis-arylazaazkanes derivatives compliance with the calculated pharmacophoric models of biaromatic ligands of cardioprotective drugs biotargets Abstract   PDF (Rus)
G. V. Mokrov, A. S. Pantileev, T. Yu. Vorobieva, V. E. Biryukova, S. A. Kryzhanovskii, V. L. Dorofeev
 
No 2 (2020) Analysis of sparse data in pharmacokinetic studies Abstract   PDF (Rus)
I. I. Miroshnichenko, A. N. Simonov, I. I. Kuzmin, A. I. Platova
 
No 4 (2016) Analysis of the light peptide fraction of Laennec by proteomic methods Abstract   PDF (Rus)
I. Yu. Torshin, V. G. Zgoda, O. A. Gromova, I. I. Baranov, V. I. Demidov, O. A. Nazarenko, N. Yu. Sotnikova, I. M. Karimova
 
No 3 (2017) Animal models of depression Abstract   PDF (Rus)
T. L. Garibova, V. A. Kraineva, T. A. Voronina
 
No 4 (2018) Antarite - synergistic combination of «magaldrat + simethicone» with gastroprotective properties Abstract   PDF (Rus)
I. Yu. Torshin, O. A. Gromova, N. A. Kuricina
 
No 2 (2021) Antiarrhythmic properties of N-Deacetyllappaconitine Hydrochloride Abstract   PDF (Rus)
S. A. Kryzhanovskii, M. S. Yunusov, I. B. Tsorin, V. V. Barchukov, E. I. Barchukova
 
No 3 (2024) Anticancer activity of tyrosine kinase TrkA receptors antagonist GK-1 in experiment on mice with mammary gland adenocarcinoma Ca755 Abstract   PDF (Rus)
L. P. Kovalenko, P. Yu. Povarnina, R. V. Zhurikov, S. V. Alekseeva, L. G. Kolik, T. A. Gudasheva, A. D. Durnev, V. I. Dorofeev
 
No 2 (2016) Anticonvulsant effect of the derived 4-benzoylpyridine (giz-298) on paroxysmal activity in the brain structures of rats with cobalt-induced focal epilepsy in the first stage of the formation of epileptic system Abstract   PDF (Rus)
T. A. Voronina, O. I. Gaidukov, S. A. Litvinova, L. N. Nerobkova, L. A. Gmurenko
 
No 3 (2023) Antidepressant activity of the pyrrolo[1,2a][1,4]diazepine GMAL-24 in a forced swimming test in mice Abstract   PDF (Rus)
A. O. Korolev, A. V. Volkova, Ya. S. Kozin, G. V. Mokrov, T. A. Voronina, T. S. Kalinina
 
No 4 (2019) Antidepressant-like activity of the dipeptide mimetic of brain-derived neurotrophic factor GSB-106 in Porsolt test after intraperitoneal sub-chronically and chronically treatment in mice Abstract   PDF (Rus)
A. V. Tallerova, P. Y. Povarnina, S. V. Minaev, T. A. Gudasheva, S. B. Seredenin
 
No 3 (2022) Anti-inflammatory properties of 5-hydroxypirimidine derivatives on the model of CFA-induced paw and ankle joint edema in rats Abstract   PDF (Rus)
R. V. Zhurikov, L. P. Kovalenko, S. V. Nikitin
 
No 2 (2018) Antiischemic properties of the Trka-receptor agonist, the nerve growth factor 4-th loop mimetic Abstract   PDF (Rus)
E. S. Pekeldina, E. O. Ionova, I. A. Mirochkina, A. V. Sorokina, V. N. Stolyaruk, I. B. Tsorin, T. A. Gudacheva, S. A. Kryzhanovskii
 
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