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Pharmacokinetics and Pharmacodynamics

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PRECLINICAL PHARMACODYNAMICS STUDIES

 
Issue Title
 
No 1 (2026) Study of the neuroprotective effect of NT-3 dipeptide mimetics GTS-301 and GTS-302 on an experimental model of ischemic stroke Abstract   PDF (Rus)
D. M. Nikiforov, P. Yu. Povarnina, T. A. Gudasheva
 
No 1 (2026) Effect of 2-isobutyl-4,6-dimethyl-5-oxypyrimidine hydrochloride with antitumor activity on the cell cycle phases in the Jurkat model Abstract   PDF (Rus)
R. V. Zhurikov, A. A. Sokolovskaya, L. P. Kovalenko, L. G. Kolik
 
No 1 (2026) Models for the pre-clinical study of ischemic and hemorrhagic stroke Abstract   PDF (Rus)
T. S. Ganshina, T. A. Voronina, S. A. Litvinova, A. V. Gnezdilova, V. L. Dorofeev
 
No 1 (2026) Effect of cyclooxygenase inhibitors, ethylmethylhydroxypyridine succinate and their combinations in a collagen-induced arthritis model in BALB/c mice Abstract   PDF (Rus)
E. A. Ivanova, A. G. Vasilchuk, N. N. Zolotov, T. A. Voronina
 
No 4 (2025) Effect of fabomotizole on behavioral features in Wistar rats with an autism spectrum disorder model induced by prenatal administration of propionic acid during the pubertal period Abstract   PDF (Rus)
V. S. Boyarkin, I. G. Kapitsa, T. A. Voronina
 
No 3 (2025) Doxorubicin dose-dependently induces cognitive impairment and anxiety in conditioned passive avoidance and elevated plus-maze tests in rats Abstract   PDF (Rus)
S. O. Kotel’nikova, I. V. Alekseev, V. A. Kraineva, T. A. Voronina, L. G. Kolik
 
No 3 (2025) Neurochemical aspects of the cardiotropic compound ALM-802S pharmacological activity Abstract   PDF (Rus)
I. B. Tsorin, L. G. Kolik, M. B. Vititnova, V. V. Barchukov, G. V. Mokrov, V. S. Kudrin, S. A. Kryzhanovsky
 
No 2 (2025) Temgicoluril exhibits anticonvulsant properties on experimental models of primary generalized epilepsy Abstract   PDF (Rus)
E. G. Aleksandrova, T. R. Abakumova, A. R. Mishin, L. E. Ziganshina
 
No 2 (2025) Аntimetastatic activity of the phenylsulfonyl-L-proline derivative AL-828, a matrix metalloproteinase-2 inhibitor, in a male C57BL/6 mouse model of Lewis lung carcinoma Abstract   PDF (Rus)
O. S. Grigorkevich, L. P. Kovalenko, G. V. Mokrov, L. G. Kolik, T. A. Gudasheva, V. L. Dorofeev
 
No 1 (2025) Study of anxiolytic activity and possible side effects of the dipeptide ligand of the translocator protein TSPO — compound GD-102 in a wide range of doses in behavioral experiments using rats and mice Abstract   PDF (Rus)
S. O. Kotel'nikova, O. A. Deeva, V. A. Kraineva, T. A. Gudasheva, T. A. Voronina, V. L. Dorofeev
 
No 1 (2025) Study of the possibility of using metformin by intranasal administration for the correction of behavioral and cognitive dysfunctions of rats Abstract   PDF (Rus)
A. Z. Hafizova, I. I. Semina
 
No 1 (2025) The study of antiparkinsonian activity of the combination of ladasten with fabomotizole in paraquat-induced model of parkinsoian syndrome Abstract   PDF (Rus)
V. E. Marievskii, İ. A. Lyubanskii, S. V. Shangin, L. F. Zainullina, V. L. Dorofeev
 
No 4 (2024) Involvement of TRK receptors in the nootropic effect of cycloprolylglycine Abstract   PDF (Rus)
O. N. Vorontsova, A. G. Alyaeva, K. N. Koliasnikova, P. Yu. Povarnina, T. A. Gudasheva, V. L. Dorofeev
 
No 4 (2024) Нepatoprotective еffects of lithium ascorbate on a model of nonalcoholic fatty liver disease with iron overload Abstract   PDF (Rus)
T. E. Bogacheva, A. G. Kalacheva, O. A. Gromova, I. Yu. Torshin, T. R. Grishina, A. A. Garanin
 
No 4 (2024) The cardiotropic properties of ZMEI-3 compound – a potential inhibitor of Epac proteins Abstract   PDF (Rus)
S. A. Kryzhanovskii, G. V. Mokrov, I. B. Tsorin, E. O. Ionova, M. B. Vititnova, V. N. Stolyaruk, I. A. Miroshkina, A. V. Sorokina, A. D. Durnev
 
No 3 (2024) Synthesis and the antidepressant-like activity investigation of bis-(N-monosuccinyl-D-seryl-D-lysine) hexamethylenediamide, the DD-enantiomer of the BDNF dipeptide mimetic, compound GSB-106 Abstract   PDF (Rus)
N. M. Sazonova, A. V. Tarasyuk, M. Yu. Filippova, M. V. Melnikova, D. M. Nikiforov, P. Yu. Povarnina, T. A. Gudasheva, V. L. Dorofeev
 
No 3 (2024) Effects of CAPAH, memantine, and rivastigmine on behavioral and cognitive functions of rats Abstract   PDF (Rus)
D. O. Nikitin, I. I. Semina, A. V. Valeeva, A. V. Nikitina, A. Z. Khafizova, A. G. Ovchinnikova
 
No 3 (2024) Anticancer activity of tyrosine kinase TrkA receptors antagonist GK-1 in experiment on mice with mammary gland adenocarcinoma Ca755 Abstract   PDF (Rus)
L. P. Kovalenko, P. Yu. Povarnina, R. V. Zhurikov, S. V. Alekseeva, L. G. Kolik, T. A. Gudasheva, A. D. Durnev, V. I. Dorofeev
 
No 3 (2024) Effect of cyclo-L-prolylglycine on pain response thresholds and morphine-induced analgesia in inbred BALB/c and C57Bl/6 mice Abstract   PDF (Rus)
A. V. Nadorova, K. N. Koliasnikova, I. V. Chernyakova, L. G. Kolik
 
No 2 (2024) Possible approaches to reproduction of endothelial dysfunction. searching for the optimal model Abstract   PDF (Rus)
I. B. Tsorin, L. V. Kozhevnikova, S. A. Simonenko, I. F. Sukhanova, M. B. Vititnova, S. A. Kryzhanovskii
 
No 2 (2024) Experimental study of the anti-inflammatory activity of diclofenac in ultra-low doses on a model of acute carrageenan inflammation Abstract   PDF (Rus)
O. A. Makhmudova, G. F. Avkhadieva, V. N. Khaziakhmetova, D. O. Nikitin, I. I. Semina
 
No 2 (2024) “Holiday heart” syndrome in rats: Features of microcirculation, functional state and anatomy of the heart Abstract   PDF (Rus)
S. A. Kryzhanovskii, I. B. Tsorin, E. O. Ionova, M. B. Vititnova, S. A. Simonenko, L. G. Kolik
 
No 2 (2024) Behavioral features of Wistar rats in models of autism spectrum disorders induced by prenatal or postnatal administration of sodium valproate Abstract   PDF (Rus)
E. V. Savinkova, I. G. Kapitsa, T. A. Voronina
 
No 2 (2024) Blood microcirculation under conditions of a translational model of alcohol cardiomyopathy in rats Abstract   PDF (Rus)
S. A. Kryzhanovskii, I. B. Tsorin, E. O. Ionova, S. A. Simonenko, M. B. Vititnova
 
No 2 (2024) Experimental model of autism spectrum disorder induced by prenatal administration of propionic acid to Wistar rats Abstract   PDF (Rus)
V. S. Boyarkin, I. G. Kapitsa, T. A. Voronina
 
No 1 (2024) A study on the mnemotropic and antidepressant-like effects of the low-molecular-weight mimetic of nerve growth factor, dipeptide GK-2, in experimental ischemic stroke Abstract   PDF (Rus)
P. Yu. Povarnina, N. M. Sazonova, D. M. Nikiforov, T. A. Gudasheva, V. L. Dorofeev
 
No 1 (2024) The possibility of calculating optimal doses in combined medicinal product (Working hypothesis) Abstract   PDF (Rus)
I. B. Tsorin, S. A. Kryzhanovskii
 
No 3 (2023) Experimental investigation of the behavioral effects of new phosphorylated thiosemicarbazides Abstract   PDF (Rus)
A. V. Nikitina, I. I. Semina, D. O. Nikitin, E. L. Gavrilova, I. A. Krutov, A. O. Isaeva
 
No 3 (2023) Antidepressant activity of the pyrrolo[1,2a][1,4]diazepine GMAL-24 in a forced swimming test in mice Abstract   PDF (Rus)
A. O. Korolev, A. V. Volkova, Ya. S. Kozin, G. V. Mokrov, T. A. Voronina, T. S. Kalinina
 
No 3 (2023) Study of the relationship between the severity of alcoholic cardiomyopathy and the level of alcohol consumption in male and female rats in the model of “home drinking” Abstract   PDF (Rus)
S. A. Kryzhanovskii, I. B. Tsorin, E. O. Ionova, V. V. Barchukov, V. N. Stolyaruk, M. B. Vititnova, L. G. Kolik, A. D. Durnev
 
No 3 (2023) Pharmacological activity of calcium lactate on a model of dysbiosis in rats Abstract   PDF (Rus)
N. L. Polyuga, E. I. Trofimets, K. E. Borovkova, L. R. Nikiforova, Ju. V. Salmova, A. A. Peleshok, K. L. Kryshen, M. N. Makarova, A. M. Kolodkin, D. E. Mitereva, I. S. Kasatkina
 
No 3 (2023) Neuropeptide cyclo-L-prolylglycine counteracts scopolamine-induced long-term memory impairment in rats in the novel object recognition test Abstract   PDF (Rus)
O. N. Vorontsova, A. G. Alyaeva, K. N. Koliasnikova, E. A. Valdman, P. Yu. Povarnina
 
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