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Pharmacokinetics and Pharmacodynamics

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PRECLINICAL PHARMACODYNAMICS STUDIES

 
Issue Title
 
No 1 (2025) Study of anxiolytic activity and possible side effects of the dipeptide ligand of the translocator protein TSPO — compound GD-102 in a wide range of doses in behavioral experiments using rats and mice Abstract   PDF (Rus)
S. O. Kotel'nikova, O. A. Deeva, V. A. Kraineva, T. A. Gudasheva, T. A. Voronina, V. L. Dorofeev
 
No 1 (2025) Study of the possibility of using metformin by intranasal administration for the correction of behavioral and cognitive dysfunctions of rats Abstract   PDF (Rus)
A. Z. Hafizova, I. I. Semina
 
No 1 (2025) The study of antiparkinsonian activity of the combination of ladasten with fabomotizole in paraquat-induced model of parkinsoian syndrome Abstract   PDF (Rus)
V. E. Marievskii, İ. A. Lyubanskii, S. V. Shangin, L. F. Zainullina, V. L. Dorofeev
 
No 4 (2024) Involvement of TRK receptors in the nootropic effect of cycloprolylglycine Abstract   PDF (Rus)
O. N. Vorontsova, A. G. Alyaeva, K. N. Koliasnikova, P. Yu. Povarnina, T. A. Gudasheva, V. L. Dorofeev
 
No 4 (2024) The cardiotropic properties of ZMEI-3 compound – a potential inhibitor of Epac proteins Abstract   PDF (Rus)
S. A. Kryzhanovskii, G. V. Mokrov, I. B. Tsorin, E. O. Ionova, M. B. Vititnova, V. N. Stolyaruk, I. A. Miroshkina, A. V. Sorokina, A. D. Durnev
 
No 4 (2024) Нepatoprotective еffects of lithium ascorbate on a model of nonalcoholic fatty liver disease with iron overload Abstract   PDF (Rus)
T. E. Bogacheva, A. G. Kalacheva, O. A. Gromova, I. Yu. Torshin, T. R. Grishina, A. A. Garanin
 
No 3 (2024) Synthesis and the antidepressant-like activity investigation of bis-(N-monosuccinyl-D-seryl-D-lysine) hexamethylenediamide, the DD-enantiomer of the BDNF dipeptide mimetic, compound GSB-106 Abstract   PDF (Rus)
N. M. Sazonova, A. V. Tarasyuk, M. Yu. Filippova, M. V. Melnikova, D. M. Nikiforov, P. Yu. Povarnina, T. A. Gudasheva, V. L. Dorofeev
 
No 3 (2024) Effects of CAPAH, memantine, and rivastigmine on behavioral and cognitive functions of rats Abstract   PDF (Rus)
D. O. Nikitin, I. I. Semina, A. V. Valeeva, A. V. Nikitina, A. Z. Khafizova, A. G. Ovchinnikova
 
No 3 (2024) Anticancer activity of tyrosine kinase TrkA receptors antagonist GK-1 in experiment on mice with mammary gland adenocarcinoma Ca755 Abstract   PDF (Rus)
L. P. Kovalenko, P. Yu. Povarnina, R. V. Zhurikov, S. V. Alekseeva, L. G. Kolik, T. A. Gudasheva, A. D. Durnev, V. I. Dorofeev
 
No 3 (2024) Effect of cyclo-L-prolylglycine on pain response thresholds and morphine-induced analgesia in inbred BALB/c and C57Bl/6 mice Abstract   PDF (Rus)
A. V. Nadorova, K. N. Koliasnikova, I. V. Chernyakova, L. G. Kolik
 
No 2 (2024) “Holiday heart” syndrome in rats: Features of microcirculation, functional state and anatomy of the heart Abstract   PDF (Rus)
S. A. Kryzhanovskii, I. B. Tsorin, E. O. Ionova, M. B. Vititnova, S. A. Simonenko, L. G. Kolik
 
No 2 (2024) Behavioral features of Wistar rats in models of autism spectrum disorders induced by prenatal or postnatal administration of sodium valproate Abstract   PDF (Rus)
E. V. Savinkova, I. G. Kapitsa, T. A. Voronina
 
No 2 (2024) Blood microcirculation under conditions of a translational model of alcohol cardiomyopathy in rats Abstract   PDF (Rus)
S. A. Kryzhanovskii, I. B. Tsorin, E. O. Ionova, S. A. Simonenko, M. B. Vititnova
 
No 2 (2024) Experimental model of autism spectrum disorder induced by prenatal administration of propionic acid to Wistar rats Abstract   PDF (Rus)
V. S. Boyarkin, I. G. Kapitsa, T. A. Voronina
 
No 2 (2024) Possible approaches to reproduction of endothelial dysfunction. searching for the optimal model Abstract   PDF (Rus)
I. B. Tsorin, L. V. Kozhevnikova, S. A. Simonenko, I. F. Sukhanova, M. B. Vititnova, S. A. Kryzhanovskii
 
No 2 (2024) Experimental study of the anti-inflammatory activity of diclofenac in ultra-low doses on a model of acute carrageenan inflammation Abstract   PDF (Rus)
O. A. Makhmudova, G. F. Avkhadieva, V. N. Khaziakhmetova, D. O. Nikitin, I. I. Semina
 
No 1 (2024) A study on the mnemotropic and antidepressant-like effects of the low-molecular-weight mimetic of nerve growth factor, dipeptide GK-2, in experimental ischemic stroke Abstract   PDF (Rus)
P. Yu. Povarnina, N. M. Sazonova, D. M. Nikiforov, T. A. Gudasheva, V. L. Dorofeev
 
No 1 (2024) The possibility of calculating optimal doses in combined medicinal product (Working hypothesis) Abstract   PDF (Rus)
I. B. Tsorin, S. A. Kryzhanovskii
 
No 3 (2023) Pharmacological activity of calcium lactate on a model of dysbiosis in rats Abstract   PDF (Rus)
N. L. Polyuga, E. I. Trofimets, K. E. Borovkova, L. R. Nikiforova, Ju. V. Salmova, A. A. Peleshok, K. L. Kryshen, M. N. Makarova, A. M. Kolodkin, D. E. Mitereva, I. S. Kasatkina
 
No 3 (2023) Neuropeptide cyclo-L-prolylglycine counteracts scopolamine-induced long-term memory impairment in rats in the novel object recognition test Abstract   PDF (Rus)
O. N. Vorontsova, A. G. Alyaeva, K. N. Koliasnikova, E. A. Valdman, P. Yu. Povarnina
 
No 3 (2023) Features of the compound ALM-802 antiarrhythmic action Abstract   PDF (Rus)
V. V. Barchukov, V. P. Zinchenko, I. B. Tsorin, I. Yu. Teplov, V. N. Stolyaruk, M. B. Vititnova, G. V. Mokrov, S. A. Kryzhanovskii
 
No 3 (2023) Experimental investigation of the behavioral effects of new phosphorylated thiosemicarbazides Abstract   PDF (Rus)
A. V. Nikitina, I. I. Semina, D. O. Nikitin, E. L. Gavrilova, I. A. Krutov, A. O. Isaeva
 
No 3 (2023) Antidepressant activity of the pyrrolo[1,2a][1,4]diazepine GMAL-24 in a forced swimming test in mice Abstract   PDF (Rus)
A. O. Korolev, A. V. Volkova, Ya. S. Kozin, G. V. Mokrov, T. A. Voronina, T. S. Kalinina
 
No 3 (2023) Study of the relationship between the severity of alcoholic cardiomyopathy and the level of alcohol consumption in male and female rats in the model of “home drinking” Abstract   PDF (Rus)
S. A. Kryzhanovskii, I. B. Tsorin, E. O. Ionova, V. V. Barchukov, V. N. Stolyaruk, M. B. Vititnova, L. G. Kolik, A. D. Durnev
 
No 2 (2023) Combined effect of fabomotizol and the compound ALM-802 on atrial depolarization in a translational model of alcoholic cardiomyopathy in rats Abstract   PDF (Rus)
S. L. Smirnova, I. M. Roshchevskaya, V. V. Barchukov, I. B. Tsorin, S. A. Kryzhanovskii
 
No 2 (2023) Study of the antiarrhythmic activity of linear alkoxyphenylazalkanes in the model of reperfusion arrythmias in rats Abstract   PDF (Rus)
V. V. Barchukov, V. N. Stolyaruk, I. B. Tsorin, M. B. Vititnova, S. А. Kryzhanovskii, T. Yu. Vorobieva, V. E. Biryukova, G. V. Mokrov
 
No 1 (2023) Validation of ELISA Test-system for Trastuzumab (Herceptin, Hertikad) quantitative determination in biological fluids Abstract   PDF (Rus)
V. V. Pisarev, A. V. Ivanov
 
No 2 (2022) Effects of pantogam active on behavior and neuroreceptor spectrum in mouse model of attention deficit disorder Abstract   PDF (Rus)
N. A. Sukhorukova, E. V. Vasileva, E. A. Kondrakhin, R. M. Salimov, G. I. Kovalev
 
No 2 (2022) The effect of fabomotizole on blood microcirculation in intact and ischemic myocardium Abstract   PDF (Rus)
I. B. Tsorin, S. A. Simonenko, M. B. Vititnova, S. A. Kryzhanovskiy
 
No 1 (2022) The mimetic of the brain neurotrophic factor GSB-106 has neuroprotective and neuroregenerative effects in experimental ischemic stroke Abstract   PDF (Rus)
P. Yu. Povarnina, T. A. Antipova, I. O. Logvinov, D. M. Nikiforov
 
No 1 (2022) Effect of the combination of mexidol and diclofenac sodium on exudative inflammation in rats after ten-day preventive oral administration Abstract   PDF (Rus)
E. A. Ivanova, A. G. Vasilchuk, A. I. Matyushkin, T. A. Voronina
 
No 1 (2022) Study of diazepam effects on Ehrlich ascites carcinoma and anxiety responses in male SHK mice Abstract   PDF (Rus)
T. S. Kalinina, A. A. Shimshirt, K. V. Lisitskaya, A. V. Volkova, N. V. Kudryashov
 
No 1 (2022) Selank effects on morphine-induced analgesia in vivo experiments Abstract   PDF (Rus)
A. V. Nadorova, I. V. Chernyakova, L. G. Kolik
 
No 4 (2021) Study of the effect of the VEGF receptor blockade on the antiischemic activity of the compound GK-2 in a rat hind limb ischemia model Abstract   PDF (Rus)
E. S. Pekeldina, I. A. Miroshkina, A. V. Sorokina, N. M. Sazonova, M. B. Vititnova, S. A. Kryzhanovskiy
 
No 4 (2021) Investigation of the fabomotizol dihydrochloride effect on the morphological picture of the heart left ventricle in rats with the subacute myocardial infarction Abstract   PDF (Rus)
I. A. Miroshkina, A. V. Sorokina, I. B. Tsorin, V. N. Stolyaruk, M. B. Vititnova, S. A. Kryzhanovskiy, A. D. Durnev
 
No 4 (2021) To the possibility of detecting the "coronary theft" syndrome in small laboratory animals Abstract   PDF (Rus)
I. B. Tsorin, S. A. Simonenko, M. B. Vititnova, S. A. Kryzhanovskiy
 
No 3 (2021) Gender differences in the formation of the epileptic system in male and female rats depending on the stage of the estrous cycle on the model of focal cobalt epilepsy Abstract   PDF (Rus)
T. A. Voronina, S. A. Litvinova, Y. B. Filatova
 
No 3 (2021) Dynamics of the cardioelectric field of rats under chronic exposure to doxorubicin during atrial depolarization Abstract   PDF (Rus)
S. L. Smirnova, O. V. Suslonova, I. M. Roshchevskaya
 
No 2 (2021) Antiarrhythmic properties of N-Deacetyllappaconitine Hydrochloride Abstract   PDF (Rus)
S. A. Kryzhanovskii, M. S. Yunusov, I. B. Tsorin, V. V. Barchukov, E. I. Barchukova
 
No 2 (2021) Effect of ethylmethylhydroxypyridine succinate on the functional activity of the transporter P-glycoprotein in the blood-brain barrier of rats under normal conditions and under hypoxic hypoxia Abstract   PDF (Rus)
P. Yu. Mylnikov, A. V. Shchulkin, I. V. Chernykh, E. N. Yakusheva
 
No 1 (2021) Evaluation of the antitumor activity of 2-[3-(2-chloroethyl)-3-nitrosoureido]-1,3-propanediol (chlonisol) in C57BL/6 mice with intracranially transplanted B16 melanoma Abstract   PDF (Rus)
I. G. Murazov, A. N. Stukov, Iu. G. Zmitrichenko, A. O. Niuganen, G. V. Tochilnikov, D. Ch. Latipova, L. V. Filatova, T. Yu. Semiglazova
 
No 1 (2021) Comparative evaluation of echocardiographic characteristics of the heart left ventricle in female and male rats Abstract   PDF (Rus)
E. O. Ionova, E. I. Barchukova, M. B. Vititnova, I. B. Tsorin, S. A. Kryzhanovskii
 
No 1 (2021) Cardioprotective effects of compound ALM-802 on subendocardial ischemia models Abstract   PDF (Rus)
I. B. Tsorin, V. V. Barchukov, M. B. Vititnova, A. M. Likhosherstov, G. V. Mokrov, S. A. Kryzhanovskii
 
No 4 (2020) Effect of the compound GIZH -290 and levetiracetam on epileptic activity in rat brain structures on EEG models of bemegrid-induced seizures Abstract   PDF (Rus)
T. A. Voronina, S. A. Litvinova, I. G. Kovalev
 
No 4 (2020) Effect of nerve growth factor dimeric mimetic GK-2 on microcirculation in skeletal muscle on the hind limb ischemia model in rats Abstract   PDF (Rus)
I. B. Tsorin, A. O. Efimova, E. S. Pekeldina, M. B. Vititnova, S. A. Kryzhanovskii
 
No 3 (2020) Comparative study of the neuroprotective activity of lithium compounds and their effect on the course of experimental alloxan diabetes mellitus in rats Abstract   PDF (Rus)
O. A. Nazarenko, V. I. Demidov, O. A. Gromova, E. L. Aleksakhina, I. Yu. Torshin
 
No 2 (2020) The in vitro neuroprotective activity of analogues of N-terminus substituted glyprolines Abstract   PDF (Rus)
S. V. Nikolaev, I. O. Logvinov, K. N. Koliasnikova, E. A. Kuznetsova, P. I. Antipov, T. A. Antipova
 
No 2 (2020) Confirmation of validity of the developed translational model of chronic heart failure in rats Abstract   PDF (Rus)
I. B. Tsorin, V. V. Barchukov, E. O. Ionova, V. N. Stolayruk, M. B. Vititnova, S. A. Kryzhanovskii
 
No 1 (2020) Screening study of nerve growth factor's and brain-derived neurotrophic factor's mimetics effects at the experimental depression model Abstract   PDF (Rus)
A. G. Mezhlumyan, A. V. Tallerova, P. Yu. Povarnina, N. M. Sazonova, A. V. Tarasiuk, T. A. Gudasheva
 
No 1 (2020) Researches of the imidazole and indole derivatives cerebroprotective activity and its impact on effects of antidepressants Abstract   PDF (Rus)
I. I. Abramets, T. O. Zayka, D. V. Evdokimov, Y. V. Kuznetsov, Y. V. Sidorova
 
No 4 (2019) Study of ALM-802 orto-alkoxi analogues cardiotropic activity Abstract   PDF (Rus)
G. V. Mokrov, A. M. Likhosherstov, V. V. Barchukov, V. N. Stolyaruk, I. B. Tsorin, M. B. Vititnova, S. A. Kryzhanovskiy, T. A. Gudasheva
 
No 4 (2019) Antidepressant-like activity of the dipeptide mimetic of brain-derived neurotrophic factor GSB-106 in Porsolt test after intraperitoneal sub-chronically and chronically treatment in mice Abstract   PDF (Rus)
A. V. Tallerova, P. Y. Povarnina, S. V. Minaev, T. A. Gudasheva, S. B. Seredenin
 
No 1 (2017) The effectiveness of lithium ascorbate on chronic alcohol intoxication model Abstract   PDF (Rus)
K. V. Ostrenko, O. A. Gromova, I. S. Sardaryan, V. I. Demidov, N. Yu. Zhidomorov, I. Yu. Torshin, A. V. Pronin, V. A. Krivonogov, Yu. V. Karpunina
 
No 4 (2018) Cytoprotective properties of the nerve growth factor and brain derived neurotrophic factor dipeptidic mimetics, GK-2 AND GSB-106, in the model of oxidative stress in paramecium caudatum Abstract   PDF (Rus)
O. V. Karpukhina, A. N. Inozemtsev, K. Z. Gumargalieva, P. Yu. Povarnina, T. A. Gudasheva
 
No 1 (2017) Novel 4-benzoylpyridine oxime derivative GIZH-298 with aticonvulsant activity Abstract   PDF (Rus)
L. A. Zhmurenko, G. V. Mokrov, L. N. Nerobkova, S. A. Litvinova, I. O. Gaydukov, T. A. Voronina, T. A. Gudasheva
 
No 1 (2019) The influence of succinate-containing drugs on physical performance and recovery after exercise Abstract   PDF (Rus)
S. V. Radko, A. D. Dulepov
 
No 3 (2017) Neuroprotective effect of L-cycloprolylglycine on models neuronal cells damage in vitro Abstract   PDF (Rus)
S. V. Nikolaev, I. O. Logvinov, P. I. Antipov, K. N. Kolyasnikova, T. A. Antipova
 
No 1 (2019) Study of methoxy-group position influence on compound alm-802 cardiotropic activity Abstract   PDF (Rus)
G. V. Mokrov, A. M. Likhosherstov, V. V. Barchukov, V. N. Stolyaruk, I. B. Tsorin, M. B. Vititnova, S. A. Kryzhanovskiy, T. A. Gudasheva
 
No 3 (2017) A study of neuroprotective effect stereospecificity of dipeptide mimetic of the Brain-derived neurotrophic factor GSB-106 on the model oxidative stress in the culture hippocampal cell line HT-22 Abstract   PDF (Rus)
I. O. Logvinov, A. V. Tarasiuk, P. I. Antipov, T. A. Antipova
 
No 1 (2019) Effect of mexidol on physical and mental performance under stressogenic conditions in experiment Abstract   PDF (Rus)
I. G. Kapitsa, E. A. Ivanova, T. A. Voronina
 
No 4 (2017) Neuroprotective and anticonvulsant effects of Cerebrolysin in the experiment Abstract   PDF (Rus)
T. E. Bogacheva, A. G. Kalacheva, T. R. Grishina, O. A. Gromova, T. V. Surakova
 
No 2 (2019) Cardioelectric field on the body surface during atrial depolarization in rats with alcoholic cardiomyopathy Abstract   PDF (Rus)
S. L. Smirnova, I. M. Roshchevskaya, I. B. Tsorin, V. N. Stolyaruk, M. B. Vititnova, L. G. Kolik, S. A. Kryzhanovskii
 
No 4 (2017) The study of the effects of magnesium orotate on the model of primary generalized convulsions in rats Abstract   PDF (Rus)
A. G. Kalacheva, T. E. Bogacheva, O. A. Gromova, T. R. Grishina, V. I. Demidov
 
No 2 (2019) A comparative study of the anti-ischemic activity of trimetazidine and the compound ALM-802 under conditions of endothelial dysfunction Abstract   PDF (Rus)
V. V. Barchukov, I. B. Tsorin, A. M. Likhosherstov, M. B. Vititnova, G. V. Mokrov, S. A. Kryzhanovskii
 
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