Resume. The paper presents literature data about the interspecific differences of the pharmacokinetics of peptide drugs and the results of our own studies on the inter-specific features of the pharmacokinetics of the 3 modified analogues of endogenous neuropeptides (noopept, dilept and GB-115) in animals of 2 species (rat, rabbit) and human wich purpose of choosing the optimal extrapolation model for predicting the pharmacokinetics of new peptide drugs in humans by pharmacokinetic parameters. Interspecific differences in the pharmacokinetics of the absorption, metabolism and elimination of dipeptide preparations are established. For the dilept - methyl ester of N-caproyl-L-prolyl-L-tyrosine - dipeptide analogue of the natural neuroleptin neurotensine, using the allometric Dedric method, it was established that the pharmacokinetics in humans can be predicted from a close fit of the pharmacokinetic parameters obtained in animals. For anxiolytic GB-115, the linearity of pharmacokinetic parameters in volunteers is shown in the use of doses in the range 1-15 mg. It is shown that the half-life of the studied peptide compounds in experimental animals is a prognostically significant parameter for extrapolating their pharmacokinetics on humans. In view of the proximity of enzymatic systems in rats and humans, it is advisable to use this species of animals at the stage of studying the pharmacokinetics of the substance of new peptide compounds to obtain general information about their pharmacokinetics and the main metabolic pathways. At the stage of studying the dosage drugs forms of these compounds preference should be given to rabbits as an experimental model, due to the possibility of obtaining the entire pharmacokinetic profile in one animal and calculating individual pharmacokinetic parameters of new peptide drugs.

On this study presents the results of the use of mineral additives salsamenteria of hypocol, selenopyran and Magne-Вб on alloxan model of diabetes in rats. A significant hypoglycemic effect of Magne B6 and selenopyran. It is revealed that all connections, especially hypocol and selenopyran have a beneficial effect on the excretory function of the kidneys in alloxan diabetes: reduce the severity of polyuria, glycosuria, and proteinuria (hypocol) and creatinine concentration in the blood (hypocol and selenopyran).

In the experimental study, the effect of the vitamin-mineral complex Teravit Antistress and its individual components: Ginseng and Ginkgo Biloba on the orientation-research behavior, resistance to stress and the course of metabolic processes in laboratory rats were studied.

Resume. In vitro experiments performed on human endothelial ceLL culture (HUVEC), nerve growth factor (NGF) angiotropic effects were studied. An intact ceLL culture it was shown that NGF exhibited angiogenic properties and stimulated the initial stage of angiogenesis -tubuLogenesis at a 10^-9 M concentration, as evidenced by a statisticaLLy significant increase in the average totaL Length of microtubuLes compared with the control. Under conditions of oxidative stress, NGF neutraLizes the damaging effect of hydrogen peroxide in a high concentration (200 |±M) and not onLy shows an angioprotective effect, but aLso prevents the deveLopment of morphoLogicaL changes in nucLear chromatin, characteristic for apoptosis. Under these conditions NGF (10^-9 M) reduces statisticaLLy significant by comparison with the controL the number of ceLLs with condensed and fragmented chromatin: 44 ± 9 and 78 ± 9 (р ≤ 0,05), respectiveLy. The obtained resuLts confirm the data about the NGF angiogenic activity and indicate that under conditions of the vesseLs endotheLiaL ceLLs damage by oxidative stress, it exhibits pronounced angioprotective and anti-apoptotic activity.

An analysis of an array of publications on naturaL extracts of tsimitsifuga, sepia, sanguinaria included in the preparation KLimaktoplan, showed that only the extracts of tsimitsifugi have more than 800 studies. The main active principles of the Klimaktoplan are synergistically interacting triterpene gLycosides, cymic acid derivatives of cymicifuge and naturaL pigments - brown melanin (sepia) and red sanguinarine (extract of Canadian sanguinaria). The results of fundamental and clinical studies of molecules of natural extracts in the KlimaktopLan indicate the following pharmacologicaL effects: anti-inflammatory, antidiabetic, vasodilator, hepatoprotective, spasmolytic, antiatherosclerotic, antitumor. Combination of components in the Klimaktoplan causes the effectiveness of the drug not onLy for the treatment of hot flashes, but a comorbid pathoLogy characteristic of the postmenopausal period. The possibility of combining extracts of Cimicifuga with other natural extracts (sepia, Canadian sanguinaria, etc.) is considered.

Resume. The study of the elemental status of young people aged 19 to 25 years living in the Ivanovo region, an estimate of the prevalence of premorbid forms of health disorders and the possibility of its correction with the help of a vitamin-mineral complex containing magnesium lactate and pyridoxine.

Resume. Relevance. Ethylthiadiazolamide of acetylaminohexanoic acid is a new non-steroidal anti-inflammatory agent from derivative of 1, 3, 4-thiadiazole and acexamic acid. Purpose. Evaluation of the bioavailability of ethylthiadiazolamide of acetylaminohexanoic acid with single intragastric administration to rabbits. Materials and Methods. Pharmacokinetic studies were performed using 6 rabbits of the Chinchilla breed. The study was conducted using an open, randomized, cross-sectional scheme. Ethylthiadiazolamide of acetylaminohexanoic acid was administered intravenously at a dose of 1 mg/kg in a 0.33 % solution of dimexide or intragastrically at a dose of 1 mg/kg in 20 ml of 2 % starch mucus. Determination of analyte in blood plasma was carried out by HPLC-MS/MS method. Sample preparation was carried out by the method of blood plasma protein precipitation by acetonitrile. Chromatography was performed with an analytical column Agilent InfinityLab Poroshell 120 EC-C18 2.7 |±m 4.6 x100 mm. As a mobile phase, a mixture of acetonitrile and deionized water at the ratio 30:70 with adding 0.1 % formic acid in the isocratic mode. The identification was carried out by mass spectrometry according to MRM m/z 285.2 → m/z 130.2. Results and Discussion. The maximum content of ethylthiadiazolamide of acetylaminohexanoic acid in blood plasma was 806.8 ± 65.6 ng/ml at 1.345 ± 0.081 h after intragastric administration. The area under the pharmacokinetic curve AUC_0→36 was 5 088.1 ± 442.1 ngхh/ml, and the ratio AUC₃₆→∞/AUC_0→36 - 2,96 ± 1,59 %. Bioavailability of ethylthiadiazolamide of acetylaminohexanoic acid with intragastric administration to rabbits at a dose of 1 mg/kg as an aqueous suspension averaged 37 %. Conclusion. It is necessary to improve biopharmaceutical properties of ethylthiadiazolamide of acetylaminohexanoic acid to increase bioavailability.