The study of electrophysiological mechanisms of the action compounds LMG-124

Abstract

In vitro experiments performed on the isolated rats hippocampal neurons, the antiarrhythmic activity electrophysiological mechanisms of the complex compound LMG-124 containing an antiarrhythmic agent of the class I by Vaughan Williams, Lappaconitine hydrobromide, were studied. As the reference preparation, a prototype, Lappaconitine hydrobromide, was used. The electrical activity of the neurons was recorded by the patch-clamp method in the whole cell configuration. It is shown that the compound LMG-124 effectively inhibits the fast incoming Na+ current flowing through transmembrane potential-dependent fast Na+ channels. This effect of the LMG-124 connection is realized at the level of the open Na+ channel. As follows from the data obtained, the LMG-124 compound, in contrast to Lappaconitine hydrobromide, blocks not only Na+ channels, but also partially and K+ channels, so that it can be attributed to antiarrhythmic drugs potentially possessing anti-arrhythmic properties of the Ia class by Vaughan classification Williams.