Assessment of pharmacokinetics-pharmacodynamics relationship of tropoxine in rats
Abstract
ResuLts of precLinicaL pharmacodynamic and pharmacokinetic study of tropoxine (a new originaL antimigraine drug) after singLe intravenous administration in rats were presented. Tropoxine in significant extent suppresses constricting reactions of rat brain vesseLs, serotonin, and agonist of 5НТ2В/2С receptors. Direct reLationship between tropoxine concentrations decreasing in the rat bLood pLasma and changing of the brain circuLation associated with serotonin and m-chLorphenyLpiperazine.
About the Authors
V. P. Zherdev
FSBI «Zakusov Institute of PharmacoLogy»
Russian Federation
Russian Federation
G. B. Kolyvanov
FSBI «Zakusov Institute of PharmacoLogy»
Russian Federation
Russian Federation
A. A. Litvin
FSBI «Zakusov Institute of PharmacoLogy»
Russian Federation
Russian Federation
A. A. Novitskyi
FSBI «Zakusov Institute of PharmacoLogy»
Russian Federation
Russian Federation
T. S. Ganshina
FSBI «Zakusov Institute of PharmacoLogy»
Russian Federation
Russian Federation
A. A. Gorbunov
FSBI «Zakusov Institute of PharmacoLogy»
Russian Federation
Russian Federation
R. S. Mirzoyan
FSBI «Zakusov Institute of PharmacoLogy»
Russian Federation
Russian Federation
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Review
For citations:
Zherdev V.P., Kolyvanov G.B., Litvin A.A., Novitskyi A.A., Ganshina T.S., Gorbunov A.A., Mirzoyan R.S. Assessment of pharmacokinetics-pharmacodynamics relationship of tropoxine in rats. Pharmacokinetics and Pharmacodynamics. 2016;(3):21-25. (In Russ.)
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