Determination of the composition of pharmaceutical substances used in drugs with antiarrhythmic activity
https://doi.org/10.37489/2587-7836-2023-4-95-109
Abstract
Cardiac arrhythmias are the most common pathologies of the cardiovascular system. Allapinin® and Allaforte® from “Pharmcenter VILAR” are effective IC-class antiarrhythmic agents. The main component of these drugs is a pharmaceutical substance with INN: lappaconitine hydrobromide, which in addition to lappaconitine hydrobromide itself, contains impurities of other diterpene alkaloids. This work is devoted to a detailed analysis of the alkaloid composition of a new pharmaceutical substance isolated from roots and rhizomes, as well as from the aerial part of plants of the genus Aconite (monkshood, wolfsbane) of the Ranunculaceae family (buttercups) using chromato-mass spectrometry and NMR spectroscopy. In addition, an assessment was made of the quantitative ratios of alkaloids in several samples of pharmaceutical substances isolated from different batches of medicinal plant raw materials.
About the Authors
A. V. Rogov
“Pharmcenter VILAR” JSC
Russian Federation
Russian Federation
Anton V. Rogov - PhD, Cand. Sci. (Biology), Deputy General Director
Moscow
G. V. Mokrov
Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies
Russian Federation
Russian Federation
Grigory V. Mokrov - PhD, Cand. Chemical Sci., Leading researcher of the fine organic synthesis laboratory at the drug chemistry department
Moscow
References
1. World Health Organization: Cardiovascular diseases (CVDs). Published 2021. Accessed October 12, 2021. https://www.who.int/en/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
2. Hendren NS, Drazner MH, Bozkurt B, Cooper LT Jr. Description and Proposed Management of the Acute COVID-19 Cardiovascular Syndrome. Circulation. 2020 Jun 9;141(23):1903–1914. DOI: 10.1161/CIRCULATIONAHA.120.047349.
3. Zhan Y, Yue H, Liang W, Wu Z. Effects of COVID-19 on Arrhythmia. J Cardiovasc Dev Dis. 2022 Sep 2;9(9):292. DOI: 10.3390/jcdd9090292.
4. Patel MH, Sampath S, Kapoor A, et al. Advances in Cardiac Pacing: Arrhythmia Prediction, Prevention and Control Strategies. Front Physiol. 2021 Dec 2;12:783241. DOI: 10.3389/fphys.2021.783241.
5. Соколов СФ, Беляева ММ, Бакалов СА, Голицын СП. Лаппаконитина гидробромид и его пролонгированная форма при желудочковой экстрасистолии у больных без органической патологии сердца: эффективность и безопасность. Кардиология: Новости Мнения Обучение. 2018;6(2):29–37. DOI:10.24411/2309-1908-2018-12004. Sokolov SF, Belyaeva MM, Bakalov SA, Golitsyn SP. Lappaconitine hydrobromide and its sustained-release form in case of ventricular premature beats in patients without organic heart diseases: efficiency and safety. Cardiology: News, Opinions, Training. 2018;6(2):29–37. (In Russ.). DOI: 10.24411/2309-1908-2018-12004.
6. Соколов СФ. Аллапинин® и современные подходы к лечению нарушений ритма сердца. РМЖ. 2012;4:177–181. Sokolov SF. Allapinin® and modern approaches to the treatment of cardiac arrhythmias. RMJ. 2012;4:177–181. (In Russ.).
7. Арчакова О.А., Комаров Т.Н., Рогов А.В., и др. Определение лаппаконитина, дитерпенового алкалоида, получаемого из растений Aconitum leucostomum, и его активного метаболита N-дезацетиллаппаконитина в плазме крови и в цельной крови человека. Разработка и регистрация лекарственных средств. 2021;10(3):105–113. DOI: 10.33380/2305-2066-2021-10-3-105-113. Archakova OA, Komarov TN, Rogov AV, et al. Determination of lappaconitin, diterpene alkaloide obtained from plants Aconitum leucostomum, and its active metabolite N-desacetyllappaconitin in human plasma and blood. Razrabotka i registratsiya lekarstvennykh sredstv = Drug development & registration. 2021;10(3):105–113. (In Russ.). DOI: 10.33380/2305-2066-2021-10-3-105-113.
8. Муталова ДК, Отаева ША, Ботиров РА, и др. Количественное содержание N-дезацетиллаппаконитина во вторичных продуктах производства Аллапинина. Universum химия и биология. 2022;7(97): 35–39. DOI: 10.32743/UniChem.2022.97.7.13882. Mutalova DK, Otayeva ShA, Botirov RA et al. Quantitative content N-deacetylappaconitine in secondary products of Allapinin production. Universum Chemistry and Biology. 2022;7(97):35–39. (In Russ.). DOI: 10.32743/UniChem.2022.97.7.13882.
Review
For citations:
Rogov A.V., Mokrov G.V. Determination of the composition of pharmaceutical substances used in drugs with antiarrhythmic activity. Pharmacokinetics and Pharmacodynamics. 2023;(4):95-109. (In Russ.) https://doi.org/10.37489/2587-7836-2023-4-95-109
Views:
456
Email this article 