Absolute bioavailability of a substance with cardioprotective activity (ALM-802) in rats
https://doi.org/10.37489/2587-7836-2021-2-31-35
Abstract
The pharmacokinetics of a new potential cardioprotective agent ALM-802 was studied in rats after single intravenous and intragastric administration at doses of 10 and 100 mg/kg, respectively. The absolute bioavailability was 4.45 %, which indicates the potential for the development of a dosage form for oral administration
About the Authors
G. B. Kolyvanov
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
Kolyvanov Gennadiy B. - D. Sci. in Biology, Leading researcher of the laboratory
of pharmacokinetics
SPIN code: 2538-8639
Moscow
P. O. Bochkov
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
Bochkov Pavel O. - PhD in Biology, Senior Research Officer of laboratory
pharmacokinetics
SPIN code: 5576-8174
Moscow
A. A. Litvin
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
Litvin Alexander A. - D. Sci. in Biology, Leading researcher of the laboratory
of pharmacokinetics
SPIN code: 6193-5770
Moscow
R. V. Shevchenko
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
Shevchenko Roman V. - PhD in Medicine, Research Officer of laboratory
pharmacokinetics
SPIN code: 1844-6202
Moscow
A. L. Podolko
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
Podolko Anna L. - Junior Research Officer of laboratory pharmacokinetics
SPIN code: 4707-3068
Moscow
V. P. Zherdev
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
Zherdev Vladimir P. - D. Sci. in Medicine, professor, Head of laboratory
pharmacokinetics
SPIN code: 2213-9592
Moscow
References
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Review
For citations:
Kolyvanov G.B., Bochkov P.O., Litvin A.A., Shevchenko R.V., Podolko A.L., Zherdev V.P. Absolute bioavailability of a substance with cardioprotective activity (ALM-802) in rats. Pharmacokinetics and Pharmacodynamics. 2021;(2):31-35. (In Russ.) https://doi.org/10.37489/2587-7836-2021-2-31-35
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