Confirmation of validity of the developed translational model of chronic heart failure in rats
https://doi.org/10.37489/2587-7836-2020-2-11-16
Abstract
The exprimants based on our translational model of chronic post-infarction heart failure within the use of echocardiography showed that in animals after 90 days after the reproduction of the myocardial infarction compared to the sham operated animals there is a significant increase in the endsystolic and end-diastolic sizes of the left ventricle (respectively, from 2.49 ± 0.09 to 3.91 ± 0.17 mm, p = 0.0002, and from 3.56 ± 0.12 to 5.20 ± 0.19 mm, p = 0.0002) and the decrease of its inotropic function that indicates a simulated pathology. 5 days after the echocardiographic study, the animals' exercise tolerance was assessed in the treadmill-run to failure test. It is proved in rats that 90 days after the coronary artery litigation the tolerance of physical activity decreases sharply – the value of the distance covered by them is 109.21 ± 11.61 m, which is 2.5 times less than the distance covered by sham operated animals (p = 0.003) and 5.3 times less than the distance covered by intact rats (p = 0.0001), – which is pathognomonic for chronic heart failure and complements the data of previously conducted morpho-histological, biochemical and molecular studies, indicating that the present model reproduces the main clinical and diagnostic signs of the simulated pathology.
About the Authors
I. B. Tsorin
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Tsorin Iosif B. – D. Sci. in Biology, Leading researcher of laboratory of pharmacological screening. SPIN code: 4015-3025
Moscow
V. V. Barchukov
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Barchukov Vladimir V. – Research scientist of laboratory of pharmacological screening. SPIN code: 6743-4280
Moscow
E. O. Ionova
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Ionova Ekaterina O. – Junior Research Scientist of Laboratory of Pharmacological Screening. SPIN code: 5042-1952
Moscow
V. N. Stolayruk
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Stolyaruk Valeriy N. – PhD in Medicine, Senior Researcher Scientist of Laboratory of Pharmacological Screening
Moscow
M. B. Vititnova
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Vititnova Marina B. – PhD in Biology, Senior researcher scientist of laboratory of pharmacological screening. SPIN code: 1901-8919
Moscow
S. A. Kryzhanovskii
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Kryzhanovskii Sergey A. – D. Sci. in Medicine, Head of laboratory of pharmacological screening. SPIN code: 6596-4865
Moscow
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Review
For citations:
Tsorin I.B., Barchukov V.V., Ionova E.O., Stolayruk V.N., Vititnova M.B., Kryzhanovskii S.A. Confirmation of validity of the developed translational model of chronic heart failure in rats. Pharmacokinetics and Pharmacodynamics. 2020;(2):11-16. (In Russ.) https://doi.org/10.37489/2587-7836-2020-2-11-16
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