The metabolites of vitamin D: role in the diagnosis and in the therapy of vitamin-D-dependent pathologies
Abstract
Most studies on the relationship between vitamin D and various pathologies use only one of the metabolites of vitamin D-25-hydroxyvitamin D3 (25(OH)D3). Hence, the potential effects associated with changes in the levels of other vitamin D metabolites remain outside of the focus of most researchers. In this paper we analyze the known biotransformations of cholecalciferol, possible errors in the assessment of D deficiency related to the properties of various metabolites of vitamin D3, a fundamental biologicaL roLe of the different metabolites of vitamin D3, and prospects for the use of the determination of vitamin D3 metabolite levels for clinical diagnostics.
About the Authors
O. A. Gromova
ФГБОУ ВО «Ивановская государственная медицинская академия» Минздрава России
Russian Federation
Russian Federation
I. Yu. Torshin
ФГБОУ ВО «Московский физико-технический институт (государственный университет)»
Russian Federation
Russian Federation
A. V. Gilels
ФГБОУ ВО «Ивановская государственная медицинская академия» Минздрава России
Russian Federation
Russian Federation
T. R. Grishina
ФГБОУ ВО «Ивановская государственная медицинская академия» Минздрава России
Russian Federation
Russian Federation
I. K. Tomilova
ФГБОУ ВО «Ивановская государственная медицинская академия» Минздрава России
Russian Federation
Russian Federation
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For citations:
Gromova O.A., Torshin I.Yu., Gilels A.V., Grishina T.R., Tomilova I.K. The metabolites of vitamin D: role in the diagnosis and in the therapy of vitamin-D-dependent pathologies. Pharmacokinetics and Pharmacodynamics. 2016;(4):9-18. (In Russ.)
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