References

phkinetica

Фармакокинетика и Фармакодинамика

Pharmacokinetics and Pharmacodynamics

2587-78362686-8830

ООО «Издательство ОКИ»

phkinetica-188

Research Article

ИССЛЕДОВАНИЯ ФАРМАКОЛОГИЧЕСКОЙ АКТИВНОСТИ МЕТАБОЛИТОВ

STUDIES OF PHARMACOLOGICAL ACTIVITY OF METABOLITES

Метаболиты витамина D: роль в диагностике и терапии витамин-D-зависимых патологий

The metabolites of vitamin D: role in the diagnosis and in the therapy of vitamin-D-dependent pathologies

Громова

Ольга Алексеевна

Gromova

O. A.

unesco.gromova@gmaiL.com

Торшин

И. Ю.

Torshin

I. Yu.

noemail@neicon.ru

Гилельс

А. В.

Gilels

A. V.

noemail@neicon.ru

Гришина

Т. Р.

Grishina

T. R.

noemail@neicon.ru

Томилова

И. К.

Tomilova

I. K.

noemail@neicon.ru

ФГБОУ ВО «Ивановская государственная медицинская академия» Минздрава РоссииRussian FederationФГБОУ ВО «Московский физико-технический институт (государственный университет)»Russian Federation

2016

09112016

04918

2016

Громова О.А., Торшин И.Ю., Гилельс А.В., Гришина Т.Р., Томилова И.К.

Gromova O.A., Torshin I.Y., Gilels A.V., Grishina T.R., Tomilova I.K.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.pharmacokinetica.ru/jour/article/view/188

В большинстве исследований по изучению взаимосвязи между витамином D и заболеваниями изучаются ассоциации только одного из метаболитов витамина D-25-гидроксивитамина D3 (25(OH)D3). При этом потенциальные эффекты уровней других метаболитов витамина D остаются вне внимания большинства исследователей. В настоящей работе рассмотрены биотрансформации холекальциферола, возможные ошибки в оценке дефицита D (связанные со свойствами тех или иных метаболитов витамина D3), фундаментальные биологические роли метаболитов витамина D3 и перспективы использования оценок уровней метаболитов витамина D3 для клинической диагностики.

Most studies on the relationship between vitamin D and various pathologies use only one of the metabolites of vitamin D-25-hydroxyvitamin D3 (25(OH)D3). Hence, the potential effects associated with changes in the levels of other vitamin D metabolites remain outside of the focus of most researchers. In this paper we analyze the known biotransformations of cholecalciferol, possible errors in the assessment of D deficiency related to the properties of various metabolites of vitamin D3, a fundamental biologicaL roLe of the different metabolites of vitamin D3, and prospects for the use of the determination of vitamin D3 metabolite levels for clinical diagnostics.

метаболиты витамина Dдиагностика гиповитаминоза Dаквадетримmetabolites of vitamin Ddiagnosis of hypovitaminosis Dsolubilization of vitamin D

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The authors declare that there are no conflicts of interest present.