Cardioelectric field on the body surface during atrial depolarization in rats with alcoholic cardiomyopathy

Resume. To study the features of an atrium depolarization on the dynamics of the cardioelectric field on the body surface at rats with an alcoholic cardiomyopathy. The cardioelectric field on the body surface of rats with an alcoholic cardiomyopathy was investigated during an atrium depolarization by the method of multiple synchronous cardioelectrotopography. In experimental and control animals, reflecting atrial depolarization, is formed before the appearance of the P„ wave on the ECG, inversion of the body surface potential mapping (BSMP) regions occurs before the beginning of the ascending phase of the P„ wave. In rats of the experimental group, it is shown an increase in the heart rate, the total duration of atrial depolarization, the period of the ascending and descending phases of the P„ wave on the ECG; later (relative to the peak of the R_M-wave) inversion of the BSMP regions and the beginning of the P_II wave by comparison with the control animals. The duration of inversion in experimental rats significantly increased compared with the control. Alcoholic cardiomyopathy leads to significant changes in the spatial and temporal parameters of the cardioelectric field at the initial stages of atrium depolarization, an increase in the non-uniformity of depolarization and a high risk of atrial arrhythmias.

электрическое поле сердца, предсердия, алкогольная кардиомиопатия, белые беспородные крысы, heart electrical field, atrium, alcoholic cardiomyopathy, white outbred rats

1. Бохан Н.А., Мандель А.И., Максименко Н.Н., Михалева Л.Д. Смертельные исходы при алкогольной зависимости // Наркология. – 2007. – № 12. – С. 37-40. [Bokhan NA, Mandel’ AI, Maksimenko NN, Mikhaleva LD. Fatal outcomes in alcohol addiction. Narkologiya. 2007;12:37–40. (In Russ).]

2. Семенова В.Г., Антонова О.И., Евдокушкина Г.Н., Гаврилова Н.С. Потери населения России в 2000-2008 гг., обусловленные алкоголем: масштабы, структура, тенденции // Социальные аспекты здоровья населения. – 2010. – № 2. – С. 34–37. [Semyonova VG, Antonova OI, Evdushkina GN, Gavrilova NS. Losses of the population of Russia in 20002008 caused by alcohol: Scales, structure, and tendencies. Sotsial. Aspekty Zdorov’ya Naseleniya. 2010;22:34–37. (In Russ).]

3. Vikhert AM, Tsiplenkova VS, Cherpachenko NM. Alcoholic cardiomyopathy and sudden death. J Am Cardiol. 1986;8(1Suppl.):3a-11a.

4. Klatsky AL. Alcohol and cardiovascular health. Physiol Behav. 2010;100(1):76–81. DOI: 10.1016/j.physbeh.2009.12.019

5. Чазов Е.И. Внезапная смерть. 2013, http: // www. medicusamicus. com/ index. php?action=2x1229x1. [Chazov EI. Sudden death. 2013. http: // www. medicusamicus. com/ index.php?action=2x1229x1. (In Russ).]

6. Крыжановский С.А., Цорин И.Б., Колик Л.Г., и др. Трансляционная модель алкогольной кардиомиопатии // Молекулярная медицина. – 2015. – № 3. – C. 40–47. [ Kryzhanovskii SA, Tsorin IB, Kolik LG, et al. Translation model of alcoholic cardiomyopathy. Mol. Med. 2015;3:40–47. (In Russ).]

7. Рощевский М.П., Артеева Н.В., Коломеец Н.Л., и др. Система «КАРДИОИНФОРМ» для визуализации и анализа электрического поля сердца // Медицинский академический журнал. – 2005. – № 5. – С. 74–79. [Roshchevsky MP, Arteeva NV, Kolomeets NL, et al. The system "Cardioinform" for visualization and analysis of the heart electric field. Med. Akad. Zh. 2005;5:74–79. (In Russ).]

8. Рощевская И.М. Кардиоэлектрическое поле теплокровных животных и человека. – СПб.: Наука; 2008. [Roshchevskaya IM. Kardioelektricheskoye pole teplokrovnykh zhivotnykh i cheloveka. S-Pb.:

9. Bacharova L, Mateasik F, Krause R, et al. The effect of reduced intercellular coupling on electrocardiographic signs of left ventricular hypertrophy. J Electrocardiol. 2011;44:571–576. DOI: 10.1016/j.jelectrocard.2011.06.004

10. Рощевский М.П., Чудородова С.Л., Рощевская И.М. Отображение на поверхность тела деполяризации предсердий // Доклады Академии наук. – 2007. – Т. 412. – № 5. – С. 704–706. [Roshchevsky MP, Chudorodova SL, Roshchevskaya IM. Expression of atrial depolarization on the body surface. Doklady Biological Sciences. 2007;412(1):15–17. (In Russ).]

11. Mirvis DM. Body surface electrocardiographic mapping. Boston: Kluwer Academic Publishers; 1988.

12. Smirnova S, Ivanova L, Markel A, et al. Comparison of propagation of atrial excitation with the cardiopotential distribution on the body surface of hypertensive rats. Anadolu. Kardiol. Derg. 2012;12(3):195–199. DOI: 10.5152/akd.2012.060

13. Смирнова С.Л., Суслонова О.В., Рощевская И.М. Пространственно-временные характеристики электрического поля предсердий у крыс с экспериментально вызванной легочной гипертензией // Известия Коми научного центра УрО РАН. – 2016. – Т. 4. – № 28. – С. 67–72. [Smirnova SL, Suslonova OV, Roshchevskaya IM. Spatial-temporal characteristics of the electric field of atria in rats with experimentally induced pulmonary hypertension. Izvestia Komi N.T. 2016;4(28):67–72. (In Russ).]

14. Смирнова С.Л., Суслонова О.В., Рощевская И.М. Электрическое поле сердца на поверхности тела в период деполяризации предсердий у крыс со спонтанной артериальной гипертензией // Практическая медицина. – 2018. – Т. 1. – № 112. – С. 61–64. [Smirnova SL, Suslonova OV, Roshchevskaya IM. Cardioelectric field on the body surface during atrial depolarization in rats with spontaneous arterial hypertension. Prakticheskaya medicina. 2018; 1(112):61–64. (In Russ).]

15. Смирнова С.Л., Рощевская И.М., Рощевский М.П., идр. Деполяризация предсердий у крыс с алкогольной кардиомиопатией // Доклады Академии наук. – 2018. – Т. 479. – № 1. – С. 96–98. [Smirnova SL, Roshchevskaya IM, Roshchevsky MP, et al. Atria depolarization in rats with alcoholic cardiomyopathy. Doklady Biological Sciences. 2018;479(1):41–43. (In Russ).] DOI 10.7868/S0869565218010231