Preclinical study the pharmacokinetics of lithium ascorbate
Abstract
We have studied the effects of lithium ascorbate on the Wistar male albino rats using a dose of 1 000 mg/kg. The concentration time curves for whole blood and tissue homogenates of 10 different biological substrates were derived (the brain, the frontal lobe of the brain, heart, aorta, lungs, liver, kidneys, spleen, adrenals, femoral bone). In the framework of the tubeless analysis of the concentrations in whole blood dynamics the following values of pharmacokinetic parameters of lithium ascorbate were obtained: Cmax=50,59 |±g/l, Tmax=1,50 h, Clast=33,7 |±g/l, AUCt=1 750 |±g/l*h, MRTt = 22,9 h, Lz=0,005 1/h, T1/2=141 h, CL = 0,029 l/h, VD=5,9 l. The concentration of lithium in whole blood and in the frontal lobe of the brain remained stable for at least 40...45 hours after the concentration peak. Multicompartment pharmacokinetic analysis showed that the stabilization of the levels of lithium in the blood and in the brain is supported by a special lithium pool, reportedly consisting of adrenal glands, aorta, femur and brain.
About the Authors
A. V. Pronin
FSBI HPE «Ivanovo State Medical Academy» of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
O. A. Gromova
FSBI HPE «Ivanovo State Medical Academy» of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
I. Ju. Torshin
Moscow Institute of Physics and Technology (State University)
Russian Federation
Russian Federation
I. V. Gogoleva
FSBI HPE «Ivanovo State Medical Academy» of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
N. Ju. Zhidomorov
FSBI HPE «Ivanovo State Medical Academy» of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
I. S. Sardaryan
FSBI HE «Russian State Agrarian University - Moscow Timiryazev Agricultural Academy»
Russian Federation
Russian Federation
A. Ju. Volkov
FSBI HPE «St. Petersburg State Pediatric Medical University» of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
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Review
For citations:
Pronin A.V., Gromova O.A., Torshin I.J., Gogoleva I.V., Zhidomorov N.J., Sardaryan I.S., Volkov A.J. Preclinical study the pharmacokinetics of lithium ascorbate. Pharmacokinetics and Pharmacodynamics. 2016;(2):18-25. (In Russ.)
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