The effect of peptide anxiolytic selank on cognitive impairment induced by acute alcohol in adolescent rats
https://doi.org/10.24411/2588-0519-2019-10052
Abstract
Nadorova AV, Chernyakova IV, Kolik LG FSBI «Zakusov Institute of Pharmacology», Moscow Resume. Background. Numerous experimental and clinical data confirm the vulnerability of the adolescent brain to ethanol and the long-term cognitive effects of acute alcohol intoxication.Selank was synthesized on the base of modification of the endogenous regulatory peptide tuftsin and developed as an anxiolytic with the activating effect on mental and cognitive functions. The aim of this work was to study the selenk effects on ethanol-induced impairment in short-term memory in young rats. Methods. The effect of selank in an effective anxiolytic dose (0.3 mg/kg, i.p., twice) on ethanol-induced (3.0 g/kg, i.p., twice) memory impairment was registered in the "Novel object recognition" test in male PD35 aged rats. Results. Selank prevented ethanol-induced disturbance of short-term non-spatial memory in adolescent rats, significantly increasing the discrimination index (p < 0.01) and the recognition index (p < 0.01) of the new stimulus object. Selank per se has no statistically significant effect on memory consolidation phase in rats not exposed to alcohol. Conclusion. The obtained data suggest a corrective effect of heptapeptide analogue of taftsin on hippocampus-dependent cognitive impairment induced by alcohol.
About the Authors
Anna Nadorova
FSBI «Zakusov institute of Pharmacology»
Russian Federation
Russian Federation
Irina Chernyakova
FSBI «Zakusov institute of Pharmacology»
Russian Federation
Russian Federation
Larisa Kolik
FSBI «Zakusov institute of Pharmacology»
Russian Federation
Russian Federation
References
1. Rolland B, Naassila M. Binge drinking: current diagnostic and therapeutic issues. CNS Drugs. 2017 Mar;31(3):181–186. DOI: 10.1007/s40263-017-0413-4
2. Silvestre de Ferron B, Bennouar KE, Kervern M, et al. Two binges of ethanol a day keep the memory away in adolescent rats: key role for GLUN2B subunit. Int J Neuropsychopharmacol. 2015 Aug 6;19(1). pii: pyv087. DOI: 10.1093/ijnp/pyv087
3. Smith KW, Gierski F, Andre J, et al. Altered white matter integrity in whole brain and segments of corpus callosum, in young social drinkers with binge drinking pattern. Addict Biol. 2017 Mar;22(2):490–501. DOI: 10.1111/adb.12332
4. Taren AA, Venkatraman V, Huettel SA. A parallel functional topography between medial and lateral prefrontal cortex: evidence and implications for cognitive control. J Neurosci. 2011 Mar 30;31(13):5026–5031. DOI: 10.1523/JNEUROSCI.5762-10.2011
5. Crone EA, Bullens L, van der Plas EA, et al. Developmental changes and individual differences in risk and perspective taking in adolescence. Dev Psychopathol. 2008 Fall;20(4):1213–1229. DOI: 10.1017/S0954579408000588
6. McQueeny T, Schweinsburg BC, Schweinsburg AD, et al. Altered white matter integrity in adolescent binge drinkers. Alcohol Clin Exp Res. 2009 Jul;33(7):1278–1285. DOI: 10.1111/j.1530-0277.2009.00953.x
7. Contreras A, Morales L, Tebourbi A, et al. Age-Dependent Effects of Acute Alcohol Administration in the Hippocampal Phosphoproteome. Chem Res Toxicol. 2017 Dec 18;30(12):2165–2173. DOI: 10.1021/acs.chemrestox.7b00260
8. Drissi I, Deschamps C, Fouquet G, et al. Memory and plasticity impairment after binge drinking in adolescent rat hippocampus: GluN2A/GluN2B NMDA receptor subunits imbalance through HDAC2. Addict Biol. 2019 May 6:e12760. DOI: 10.1111/adb.12760
9. Kovács GL, Bohus B, Versteeg DH, et al. Effect of oxytocin and vasopressin on memory consolidation: sites of action and catecholaminergic correlates after local microinjection into limbic-midbrain structures. Brain Res. 1979 Oct 19;175(2):303–314.
10. Gudasheva TA, Boyko SS, Akparov VKh, et al. Identification of a novel endogenous memory facilitating cyclic dipeptide cyclo-prolylglycine in rat brain. FEBS Lett. 1996 Aug 5;391(1-2):149–152. DOI:10.1016/0014-5793(96)00722-3
11. Ашмарин И.П., Королева С.В., Мясоедов Н.Ф. Синактоны – функционально связанные комплексы эндогенных регуляторов // Экспериментальная и клиническая фармакология. – 2006. – T. 69. – № 5. – С. 3–6. [Ashmarin IP, Koroleva SV, Myasoedov NF. Sinaktony` — funkcional`no svyazanny`e kompleksy` e`ndogenny`x regulyatorov. E`ksperimental`naya i klinicheskaya farmakologiya. 2006;69(5):3–6. (In Russ).]
12. Vyunova TV, Andreeva LA, Shevchenko KV, Myasoedov NF. An integrated approach to study the molecular aspects of regulatory peptides biological mechanism. J Labelled Comp Radiopharm. 2019 Jul 20. DOI:10.1002/jlcr.3785
13. Семенова Т.П., Козловский И.И., Захарова Н.М., Козловская М.М. Оптимизация процессов обучения и памяти в эксперименте с помощью селанка // Экспериментальная и клиническая фармакология. – 2010. – Т. 73. – № 8. – С. 2–5. [Semenova TP, Kozlovskij II, Zaxarova NM, Kozlovskaya MM. Optimizaciya processov obucheniya i pamyati v e`ksperimente s pomoshh`yu selanka. E`ksperimental`naya i klinicheskaya farmakologiya. 2010;73(8):2–5. (In Russ).]
14. Козловский И.И., Белозерцев Ф.Ю., Андреева Л.А., Козловская М.М. Протективное действие селанка при нарушении мнестических функций, вызванном в эксперименте фармакологической блокадой синтеза белка // Экспериментальная и клиническая фармакология. – 2013. – Т. 76. – № 12. – С. 3–7. [Kozlovskij II, Belozercev FYu, Andreeva LA, Kozlovskaya MM. Protektivnoe dejstvie selanka pri narushenii mnesticheskix funkcij, vy`zvannom v e`ksperimente farmakologicheskoj blokadoj sinteza belka. E`ksperimental`naya i klinicheskaya farmakologiya. 2013;76(12):3–7. (In Russ).]
15. Колик Л.Г., Надорова А.В., Козловская М.М. Эффективность пептидного анксиолитика селанка при моделировании синдрома отмены у крыс с устойчивой алкогольной мотивацией // Бюллетень экспериментальной биологии и медицины. – 2014. – Т. 157. – № 1. – С. 61–65. [Kolik LG, Nadorova AВ, Kozlovskaya MM. Efficacy of peptide anxiolytic selank during modeling of withdrawal syndrome in rats with stable alcoholic motivation. Bull Exp Biol Med. 2014;157(1): 52–55. (In Russ).] DOI: 10.1007/s10517-014-2490-4
16. Колик Л.Г., Надорова А.В., Антипова Т.А., и др. Пептидный аналог тафтсина селанк защищает от этанол-индуцированного нарушения памяти, регулируя содержание BDNF в гиппокампе и префронтальной коре у крыс // Бюллетень экспериментальной биологии и медицины. – 2019 – Т. 167. – № 5. – С. 581–585. [Kolik LG, Nadorova AV, Antipova TA, et al. Peptidny`j analog taftsina selank zashhishhaet ot e`tanol-inducirovannogo narusheniya pamyati, reguliruya soderzhanie BDNF v gippokampe i prefrontal`noj kore u kry`s. Bull Exp Biol Med. 2019;167(5):581–585. (In Russ).]
17. Надорова А.В., Колик Л.Г., Клодт П.М., и др. Соотношение анксиолитического действия селанка и уровня серотонина в отдельных структурах мозга при моделировании алкогольной абстиненции у крыс // Нейрохимия. – 2014. – Т. 31. – № 2. – С. 147. [Nadorova AV, Kolik LG, Klodt PM, et al. The relationship between the anxiolytic action of selank and the level of serotonin in brain structures during the modeling of alcohol abstinence in rats. Neurochemical journal. 2014;8(2):115–120. (In Russ).] DOI: 10.1134/S1819712414020081
18. Vyunova TV, Andreeva L, Shevchenko K, Myasoedov N. Peptidebased Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity. Protein Pept Lett. 2018;25(10):914–923. DOI: 10.2174/0929866525666180925144642
19. Васильева Е.В., Кондрахин Е.А., Салимов Р.М., и др. Сравнение эффектов пептида Селанк на глутаматные рецепторы и поведение при разных путях его введения мышам BALB/C и С57BL/6. Сб. материалов Всеросс. Конф. молодых ученых с международным участием «Достижения современной фармакологической науки» и Школе фармакологов и клинических фармакологов, Рязань, РязГМУ, 22-23 октября 2015. – С. 52–55 [Vasil`eva EV, Kondraxin EA, Salimov RM, et al. Sravnenie e`ffektov peptida Selank na glutamatny`e receptory` i povedenie pri razny`x putyax ego vvedeniya my`sham BALB/C i S57BL/6. Sb. materialov Vseross.
20. Konf. molody`x ucheny`x s mezhdunarodny`m uchastiem «Dostizheniya sovremennoj farmakologicheskoj nauki» i Shkole farmakologov i klinicheskix farmakologov, Ryazan`, RyazGMU, 2015 22–23 okt:52–55. (In Russ).]
21. Antunes M, Biala G. The novel object recognition memory: neurobiology, test procedure, and its modifications. Cogn Process. 2012 May;13(2):93–110. DOI: 10.1007/s10339-011-0430-z
22. Aggleton JP, Albasser MM, Aggleton DJ, et al. Lesions of the rat perirhinal cortex spare the acquisition of a complex configural visual discrimination yet impair object recognition. Behav Neurosci. 2010 Feb;124(1):55–68. DOI: 10.1037/a0018320
23. Burke SN, Wallace JL, Nematollahi S, et al. Pattern separation deficits may contribute to age-associated recognition impairments. Behav Neurosci. 2010 Oct;124(5):559–573. DOI: 10.1037/a0020893
24. Vinader-Caerols C, Talk A, Montañés A, et al. Differential Effects of Alcohol on Memory Performance in Adolescent Men and Women with a Binge Drinking History. Alcohol Alcohol. 2017 Sep 1;52(5):610–616. DOI: 10.1093/alcalc/agx040
25. Иноземцева Л.С., Карпенко Е.А., Долотов О.В., и др. Пептид селанк регулирует экспрессию BDNF в гиппокампе крысы in vivo при интраназальном введении // Доклады Академии наук. – 2008. – Т. 421. – № 6. – С. 842–844. [Inozemceva LS, Karpenko EA, Dolotov OV, et al. Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo. Dokl Biol Sci. 2008 Jul-Aug;421:842–844. (In Russ).]
26. Crews FT, Waage HG, Wilkie MB, Lauder JM. Ethanol pretreatment enhances NMDA excitotoxicity in biogenic amine neurons: protection by brain derived neurotrophic factor. Alcohol Clin Exp Res. 1999 Nov;23(11):1834–1842.
Review
For citations:
Nadorova A., Chernyakova I., Kolik L. The effect of peptide anxiolytic selank on cognitive impairment induced by acute alcohol in adolescent rats. Pharmacokinetics and Pharmacodynamics. 2019;(3):27-33. (In Russ.) https://doi.org/10.24411/2588-0519-2019-10052
Views: 726
Email this article 