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The effect of peptide anxiolytic selank on cognitive impairment induced by acute alcohol in adolescent rats

https://doi.org/10.24411/2588-0519-2019-10052

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Abstract

Nadorova AV, Chernyakova IV, Kolik LG FSBI «Zakusov Institute of Pharmacology», Moscow Resume. Background. Numerous experimental and clinical data confirm the vulnerability of the adolescent brain to ethanol and the long-term cognitive effects of acute alcohol intoxication.Selank was synthesized on the base of modification of the endogenous regulatory peptide tuftsin and developed as an anxiolytic with the activating effect on mental and cognitive functions. The aim of this work was to study the selenk effects on ethanol-induced impairment in short-term memory in young rats. Methods. The effect of selank in an effective anxiolytic dose (0.3 mg/kg, i.p., twice) on ethanol-induced (3.0 g/kg, i.p., twice) memory impairment was registered in the "Novel object recognition" test in male PD35 aged rats. Results. Selank prevented ethanol-induced disturbance of short-term non-spatial memory in adolescent rats, significantly increasing the discrimination index (p < 0.01) and the recognition index (p < 0.01) of the new stimulus object. Selank per se has no statistically significant effect on memory consolidation phase in rats not exposed to alcohol. Conclusion. The obtained data suggest a corrective effect of heptapeptide analogue of taftsin on hippocampus-dependent cognitive impairment induced by alcohol.

About the Authors

Anna Nadorova
FSBI «Zakusov institute of Pharmacology»
Russian Federation


Irina Chernyakova
FSBI «Zakusov institute of Pharmacology»
Russian Federation


Larisa Kolik
FSBI «Zakusov institute of Pharmacology»
Russian Federation


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Nadorova A., Chernyakova I., Kolik L. The effect of peptide anxiolytic selank on cognitive impairment induced by acute alcohol in adolescent rats. Pharmacokinetics and Pharmacodynamics. 2019;(3):27-33. (In Russ.) https://doi.org/10.24411/2588-0519-2019-10052

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