Development and validation of the quantification of GIZH-298, possessing in the rat blood plasma by HPLC-UF
https://doi.org/10.24411/2587-7836-2019-10046
Abstract
He technique of quantitative determination of a new compound GIZH-298 in the rat blood plasma was developed and validated. Analysis was performed by HPLC-UV. The method was linear in the range of 100-5000 ng/ml. Recovery of GIZH-298 was 86,88 %. Limit of detection was 100 ng/ml.
About the Authors
O. G. Gribakina
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
R. V. Shevchenko
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
G. B. Kolyvanov
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
A. A. Litvin
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
P. O. Bochkov
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
S. S. Boyko
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
V. P. Zherdev
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
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Review
For citations:
Gribakina O.G., Shevchenko R.V., Kolyvanov G.B., Litvin A.A., Bochkov P.O., Boyko S.S., Zherdev V.P. Development and validation of the quantification of GIZH-298, possessing in the rat blood plasma by HPLC-UF. Pharmacokinetics and Pharmacodynamics. 2019;(2):41-45. (In Russ.) https://doi.org/10.24411/2587-7836-2019-10046
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