Pharmacokinetic study of prolonged release capsules of mebeverine
Abstract
Pharmacokinetic study of prolonged release capsules of mebeverine was carried out on 24 volunteers. It is known that the drug substance is completely metabolized due to first-pass effect. Therefore, pharmacokinetic parameters of the main metabolites -mebeverine acid and desmethyl mebeverine acid were measured. Bioanalytical method was developed to measurement of concentrations of these metabolites in blood plasma by using HPLC-MS/MS.
About the Authors
A. L. Khokhlov
The Yaroslavl State Medical University; Quinta-Analytica Yaroslavl LLC
Russian Federation
Russian Federation
Yu. A. Dzhurko
Quinta-Analytica Yaroslavl LLC
Russian Federation
Russian Federation
L. N. Shitov
The Yaroslavl State Medical University; Quinta-Analytica Yaroslavl LLC
Russian Federation
Russian Federation
I. I. Yaichkov
The Yaroslavl State Medical University; Quinta-Analytica Yaroslavl LLC
Russian Federation
Russian Federation
A. M. Shitova
Quinta-Analytica Yaroslavl LLC
Russian Federation
Russian Federation
L. A. Khozova
Quinta-Analytica Yaroslavl LLC
Russian Federation
Russian Federation
A. E. Miroshnikov
The Yaroslavl State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Khokhlov A.L., Dzhurko Yu.A., Shitov L.N., Yaichkov I.I., Shitova A.M., Khozova L.A., Miroshnikov A.E. Pharmacokinetic study of prolonged release capsules of mebeverine. Pharmacokinetics and Pharmacodynamics. 2017;(1):57-62. (In Russ.)
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