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Study of the pharmacokinetics of antituberculosis drug Biomairin

https://doi.org/ 10.24411/2587-7836-2018-10030

Abstract

Resume. The results of a studying the pharmacokinetics of the anti-tuberculosis drug Biomayrin in experimental animals (rats) after oral administration were presented. A comparative analysis of the pharmacokinetic parameters of Biomayrin with a comparing drug (a mixture of rifampicin, ethambutol and isoniazid) showed that the bioavailability of isoniazid increased four times as a part of Biomayrin, the ethambutol and rifampicin three times compared to the comparing drug, thereby showing a prolonged effect. It should also be noted that the introduction of isoniazid into the polysaccharide matrix retards its metabolism to the therapeutically inactive acetylisoniazid.

About the Authors

Sh. A. Shomurotov
Institute of Bioorganic Chemistry, Academy of Sciences of Uzbekistan
Russian Federation


E. M. Sultanova
Institute of Bioorganic Chemistry, Academy of Sciences of Uzbekistan
Russian Federation


M. K. Salakhutdinova
Institute of Bioorganic Chemistry, Academy of Sciences of Uzbekistan
Russian Federation


U. J. Ishimov
Institute of Bioorganic Chemistry, Academy of Sciences of Uzbekistan
Russian Federation


J. F. Ziyavitdinov
Institute of Bioorganic Chemistry, Academy of Sciences of Uzbekistan
Russian Federation


O. N. Veshkurova
Institute of Bioorganic Chemistry, Academy of Sciences of Uzbekistan
Russian Federation


A. S. Turaev
Institute of Bioorganic Chemistry, Academy of Sciences of Uzbekistan
Russian Federation


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Review

For citations:


Shomurotov Sh.A., Sultanova E.M., Salakhutdinova M.K., Ishimov U.J., Ziyavitdinov J.F., Veshkurova O.N., Turaev A.S. Study of the pharmacokinetics of antituberculosis drug Biomairin. Pharmacokinetics and Pharmacodynamics. 2018;(4):50-55. (In Russ.) https://doi.org/ 10.24411/2587-7836-2018-10030

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ISSN 2587-7836 (Print)
ISSN 2686-8830 (Online)