Comparison of neuroprotective properties of the dipeptide mimetics of the 1st, 2nd and 4th loops of the brain-derived neurotrophic factor on the model oxidative stress in vitro
https://doi.org/ 10.24411/2587-7836-2018-10022.
Abstract
Resume. The purpose of this study was to compare neuroprotective properties of the dimeric dipeptide mimetics of the 1st, 2nd and 4th Loops of BDNF - GSB-214 (heptamethylenediamide bis-monosuccinyl-methionyl-serine), GTS-201 (hexamethylenediamide bis-hexanoyl-seryl-lysine) and GSB-106 (hexamethylenediamide bis-monosuccinyl-seryl-lysine) in the HT-22 hippocampal cells in conditions of oxidative stress. It has been established that the mimetic of the 4th loop of BDNF shows a neuroprotective effect in lower concentrations compared to mimetics based on the 1st and 2nd loops when applied 24 hours before and immediately after the damages.
About the Authors
I. O. Logvinov
FSBI "Zakusov Institute of Pharmacology"
Russian Federation
Russian Federation
A. V. Tarasiuk
FSBI "Zakusov Institute of Pharmacology"
Russian Federation
Russian Federation
N. M. Sazonova
FSBI "Zakusov Institute of Pharmacology"
Russian Federation
Russian Federation
P. I. Antipov
FSBI "Zakusov Institute of Pharmacology"
Russian Federation
Russian Federation
T. A. Antipova
FSBI "Zakusov Institute of Pharmacology"
Russian Federation
Russian Federation
T. A. Gudasheva
FSBI "Zakusov Institute of Pharmacology"
Russian Federation
Russian Federation
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Review
For citations:
Logvinov I.O., Tarasiuk A.V., Sazonova N.M., Antipov P.I., Antipova T.A., Gudasheva T.A. Comparison of neuroprotective properties of the dipeptide mimetics of the 1st, 2nd and 4th loops of the brain-derived neurotrophic factor on the model oxidative stress in vitro. Pharmacokinetics and Pharmacodynamics. 2018;(3):37-41. (In Russ.) https://doi.org/ 10.24411/2587-7836-2018-10022.
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