Novel 4-benzoylpyridine oxime derivative GIZH-298 with aticonvulsant activity
Abstract
Novel derivative of benzoylpyridine oximes - GIZH-298 (4-benzoylpyridine 0-(2-morpholinoethyl) oxime oxalate) was designed and synthesized in this work. This compound has a broad spectrum of anticonvulsant effects, eliminating primary generalized seizures in maximal electroshock (MES) and corazol antagonism tests in rodents in the doses of 0,5-100 mg/kg. LD50 for compound GIZH-298 is 316 mg/kg intraperitoneally (mouse). GIZH-298 has a large therapeutic breadth.
About the Authors
L. A. Zhmurenko
Zakusov Research Institute of Pharmacology
Russian Federation
Russian Federation
G. V. Mokrov
Zakusov Research Institute of Pharmacology
Russian Federation
Russian Federation
L. N. Nerobkova
Zakusov Research Institute of Pharmacology
Russian Federation
Russian Federation
S. A. Litvinova
Zakusov Research Institute of Pharmacology
Russian Federation
Russian Federation
I. O. Gaydukov
Zakusov Research Institute of Pharmacology
Russian Federation
Russian Federation
T. A. Voronina
Zakusov Research Institute of Pharmacology
Russian Federation
Russian Federation
T. A. Gudasheva
Zakusov Research Institute of Pharmacology
Russian Federation
Russian Federation
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Review
For citations:
Zhmurenko L.A., Mokrov G.V., Nerobkova L.N., Litvinova S.A., Gaydukov I.O., Voronina T.A., Gudasheva T.A. Novel 4-benzoylpyridine oxime derivative GIZH-298 with aticonvulsant activity. Pharmacokinetics and Pharmacodynamics. 2017;(1):22-26. (In Russ.)
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