Pharmacoinformation analysis of the molecules of the drug Klimaktoplan
https://doi.org/ 10.24411/2587-7836-2018-10005.
Abstract
An analysis of an array of publications on naturaL extracts of tsimitsifuga, sepia, sanguinaria included in the preparation KLimaktoplan, showed that only the extracts of tsimitsifugi have more than 800 studies. The main active principles of the Klimaktoplan are synergistically interacting triterpene gLycosides, cymic acid derivatives of cymicifuge and naturaL pigments - brown melanin (sepia) and red sanguinarine (extract of Canadian sanguinaria). The results of fundamental and clinical studies of molecules of natural extracts in the KlimaktopLan indicate the following pharmacologicaL effects: anti-inflammatory, antidiabetic, vasodilator, hepatoprotective, spasmolytic, antiatherosclerotic, antitumor. Combination of components in the Klimaktoplan causes the effectiveness of the drug not onLy for the treatment of hot flashes, but a comorbid pathoLogy characteristic of the postmenopausal period. The possibility of combining extracts of Cimicifuga with other natural extracts (sepia, Canadian sanguinaria, etc.) is considered.
Keywords
менопауза,
цимицифуга,
меланин,
сепия,
сангвинарин,
Климактоплан,
menopause,
Cimicifuga,
melanin,
sepia,
sanguine,
KLimaktopLan
About the Authors
I. Yu. Torshin
FederaL Research Center “Computer Science and Control“ of the Russian Academy of Sciences
Russian Federation
Russian Federation
O. A. Gromova
FederaL Research Center “Computer Science and Control“ of the Russian Academy of Sciences
Russian Federation
Russian Federation
N. I. Tapilskaya
FederaL State Budgetary Scientific Institution “The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott”
Russian Federation
Russian Federation
References
1. Громова О.А., Торшин И.Ю., Лиманова О.А., и др. Сравнительное исследование доказательной базы эффективности и безопасности применения пероральной и трансдермальной форм заместительной гормональной терапии эстрогенами у женщин в различные возрастные периоды // Проблемы репродукции. - 2013. - Т. 19. - №6. - С. 86- 96.
2. Громова О.А., Торшин И.Ю., Тетруашвили Н.К., и др. Молекулярно-фармакологические механизмы стимуляции гиперкоагуляции препаратами пероральных и трансдермальных эстрогенов // Гинекология. - 2014. - Т. 16. - № 2. - С. 22-28.
3. Ruhlen RL, Sun GY, Sauter ER. Black Cohosh: Insights into its Mechanism(s) of Action. Integr Med Insights. 2008;3:21-32.
4. Черных В.П., Георгиянц В.А., Зупанец И.А. Клинико-фармацевтические аспекты применения комплексного препарата Климактоплан // Репродуктивное здоровье женщин. -2004, - Т. 20. - № 4. - С. 95- 98.
5. Obi N., Chang-Claude J., Berger J., et al. The use of herbal preparations to alleviate climacteric disorders and risk of postmenopausal breast cancer in a German case-control study. Cancer Epidemiol Biomarkers Prev. 2009 Aug;18(8):2207-13. DOI: 10.1158/1055-9965.EPI-09-0298
6. Guo Y., Yin T., Wang X., et al. Traditional uses, phytochemistry, pharmacology and toxicology of the genus Cimicifuga: A review. J. Ethnopharmacol. 2017 Sep 14;209:264-282. DOI: 10.1016/jjep.2017.07.040
7. Huntley A., Ernst E. A systematic review of the safety of black cohosh. Menopause. 2003 Jan-Feb;10(1):58-64.
8. Yang CL, Chik SC, Li JC, et al. Identification of the bioactive constituent and its mechanisms of action in mediating the anti-inflammatory effects of black cohosh and related Cimicifuga species on human primary blood macrophages. J. Med Chem. 2009 Nov 12;52(21):6707-6715. DOI: 10.1021/jm9006164
9. Loeer B., Kruse SO, Melzig MF, Nahrstedt A. Inhibition of neutrophil elastase activity by cinnamic acid derivatives from Cimicifuga racemosa. Planta Med. 2000 Dec;66(8):751-753. DOI: 10.1055/s-2000-9563
10. Wuttke W., Jarry H., Haunschild J., et al. 2014. The non-estrogenic alternative for the treatment of climacteric complaints: Black cohosh (Cimicifuga or Actaea racemosa). J. Steroid Biochem Mol Biol. 2014 Jan;139:302- 310. DOI: 10.1016/j.jsbmb.2013.02.007
11. Новиков В.И., Карандашов В.И., Сидорович И.Г. Иммунотерапия при злокачественных новообразованиях. - М.: Медицина; 2002.
12. Торшин И.Ю., Громова О.А., Лиманова О.А. «Быстрый эффект» бета-аланина при приливах: сравнительное исследование взаимодействий бета-аланина, таурина и глицина с глициновыми рецепторами // Гинекология. - 2012. - Т. 14. - № 2. - С. 65-69.
13. Suh KS, Choi EM, Jung WW, et al. Deoxyactein protects pancreatic □ ß-cells against methylglyoxal-induced oxidative cell damage by the upregulation of mitochondrial biogenesis. Int J. Mol Med. 2017 Aug;40(2):539- 548. DOI: 10.3892/ijmm.2017.3018
14. Meeprom A., Sompong W., Suantawee T., et al. Isoferulic acid prevents methylglyoxal-induced protein glycation and DNA damage by free radical scavenging activity. BMC Complement Altern Med. 2015 Oct 5;15:346. DOI: 10.1186/s12906-015-0874-2
15. Moser C., Vickers SP, Brammer R., et al. Antidiabetic effects of the Cimicifuga racemosa extract Ze 450 in vitro and in vivo in ob/ob mice. Phytomedicine. 2014 Sep 25;21(11):1382- 1389. DOI: 10.1016/j.phymed.2014.06.002
16. Noguchi M., Nagai M., Koeda M., et al. Vasoactive effects of cimicifugic acids C. and D., and fukinolic acid in cimicifuga rhizome. Biol Pharm Bull. 1998 Nov;21(11):1163- 1168.
17. Kim EY, Lee YJ, Rhyu MR. Black cohosh (Cimicifuga racemosa) relaxes the isolated rat thoracic aorta through endothelium-dependent and -independent mechanisms. J. Ethnopharmacol. 2011 Nov 18;138(2):537- 542. DOI: 10.1016/j.jep.2011.09.048
18. Zheng TP, Sun AJ, Xue W., et al. Efficacy and safety of Cimicifuga foetida extract on menopausal syndrome in Chinese women. Chin Med J. (Engl). 2013;126(11):2034-2038.
19. Campos LB, Gilglioni EH, Garcia RF, et al. Cimicifuga racemosa impairs fatty acid D-oxidation and induces oxidative stress in livers of ovariectomized rats with renovascular hypertension. Free Radic Biol Med. 2012 Aug 15;53(4):680- 689. DOI: 10.1016/j.freeradbiomed.2012.05.043
20. Можейко М.Е., Потанина М.В., Сударева Н.В., и др. Артериальная гипертония и климактерический синдром у женщин в постменопаузе: особенности лечения. Клиническая геронтология. - 2008. -Т. 14. - № 3. - С. 25-28.
21. Wang KC, Chang JS, Chiang LC, Lin CC. Cimicifuga foetida L. Inhibited Human Respiratory Syncytial Virus in HEp-2 and A549 Cell Lines. Am J. Chin Med. 2012;40(1):151- 162. DOI: 10.1142/S0192415X12500127
22. Wang KC, Chang JS, Lin LT, et al. Antiviral effect of cimicifugin from Cimicifuga foetida against human respiratory syncytial virus. Am J. Chin Med. 2012;40(5):1033- 1045. DOI: 10.1142/S0192415X12500760
23. Dai XF, Yi XF, Sun ZQ, Ruan P. Cimicifuga foetida L. plus adefovir effectively inhibits the replication of hepatitis B. virus in patients with chronic hepatitis B. Biomed Rep. 2016 Apr;4(4):493- 497. DOI: 10.3892/br.2016.601
24. Абакарова П.Р., Прилепская В.Н. ВПЧ-ассоциированные заболевания шейки матки. Возможности комплексной терапии // Гинекология. - 2017. - № 05. - С. 4-9.
25. Yamahara J., Kobayashi M., Kimura H., et al. Biologically Active Principles of Crude Drugs: The Effect of Cimicifugae Rhizoma and Constituents in Preventiive Action on the Carbon Tetrachloride-Induced Liver Disorder in Mice. Shoyakugaku Zasshi. 1985;39(1):80- 84.
26. Kong Y., Li F., Nian Y., Zhou Z., Yang R., Qiu MH, Chen C. KHF16 is a Leading Structure from Cimicifuga foetida that Suppresses Breast Cancer Partially by Inhibiting the NF-nB Signaling Pathway. Theranostics. 2016 Apr 12;6(6):875-886. DOI: 10.7150/thno.14694. eCollection 2016. PMID: 27162557.
27. Zheng TP, Sun AJ, Xue W., et al. Efficacy and safety of Cimicifuga foetida extract on menopausal syndrome in Chinese women. Chin Med J. (Engl). 2013;126(11):2034-2038.
28. Парфенов В.А., Яхно Н.Н., Евзиков Г.Ю. Нервные болезни. Медицинское информационное агентствоя; 2018.
29. Zhu dF, Zhu GL, Kong LM, et al. Cycloartane Glycosides from the Roots of Cimicifuga foetida with Wnt Signaling Pathway Inhibitory Activity. Nat Prod Bioprospect. 2015 Feb 19;5(2):61-67. DOI: 10.1007/s13659-015-0053-7
30. Findeis MA, Schroeder F., McKee TD, et al. Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa. ACS Chem Neurosci. 2012 Nov 21;3(11):941- 951. DOI: 10.1021/cn3000857
31. Nian Y., Zhu H., Tang WR, Luo Y., Du J., Qiu MH. Triterpenes from the aerial parts of Cimicifuga yunnanensis and their antiproliferative effects on p53(N236S) mouse embryonic fibroblasts. J. Nat Prod. 2013 May 24;76(5):896-902. DOI: 10.1021/np4000262. Epub 2013 Apr 26.PMID:23621813
32. Xi S., Liske E., Wang S., et al. Effect of Isopropanolic Cimicifuga racemosa Extract on Uterine Fibroids in Comparison with Tibolone among Patients of a Recent Randomized, Double Blind, Parallel-Controlled Study in Chinese Women with Menopausal Symptoms. Evid Based Complement Alternat Med. 2014;2014:717686. DOI: 10.1155/2014/717686
33. Bai W., Henneicke-von Zepelin HH, Wang S., et al. Efficacy and tolerability of a medicinal product containing an isopropanolic black cohosh extract in Chinese women with menopausal symptoms: a randomized, double blind, parallel-controlled study versus tibolone. Maturitas. 2007 Sep 20;58(1):31-41. DOI: 10.1016/j.maturitas.2007.04.009
34. Баранов И.И., Серов В.Н. Климактоплан в терапии климактерического синдрома. РМЖ. - 2005. - Т. 13. - № 1. - С. 11- 14.
35. Кузнецова И.В. Растительные лекарственные средства на основе экстракта цимицифуги как безопасная альтернатива в коррекции менопаузальных симптомов // Гинекологя. - 2014. - Т. 16. - № 4. -С. 34- 38.
36. Манушарова Р.А., Черкезова Э.И. Применение Климактоплана при климактерических расстройствах в постменопаузе // Репродуктивная медицина. - 2014. - Т. 19. - № 2. - С. 27-32.
37. Зелинский А.А., Ермоленко Т.А., Самсонова В.В., и др. Оптимизация терапии климактерического синдрома в перименопаузе // Здоровье женщины. - 2012. - № 6 (72). - С. 157- 164.
38. Shahin AY, Mohammed SA. Adding the phytoestrogen Cimicifugae Racemosae to clomiphene induction cycles with timed intercourse in polycystic ovary syndrome improves cycle outcomes and pregnancy rates - a randomized trial. Gynecol Endocrinol. 2014 Jul;30(7):505- 510. DOI: 10.3109/09513590.2014.895983
39. Beani JC. [Ultraviolet A-induced DNA damage: role in skin cancer]. Bull Acad Natl Med. 2014 Feb;198(2):273-95. French. PMID: 26263704
40. Моссэ И.Б., Кострова Л.Н., Дубовик Б.В., Плотникова С.И., Молофей В.П. Влияние меланина на мутагенное действие хронического облучения и адаптивный ответ у мышей. Радиационная биология. Радиоэкология. - 1999. - Т. 39. - № 2-3. - С. 329- 333.
41. Skoczynska A., Budzisz E., Trznadel-Grodzka E., Rotsztejn H. Melanin and lipofuscin as hallmarks of skin aging. Postepy Dermatol Alergol. 2017 Apr;34(2):97- 103. DOI: 10.5114/ada.2017.67070
42. Godowski KC. Antimicrobial action of sanguinarine. J. Clin Dent. 1989 Spring;1(4):96-101.
43. Southard GL, Boulware RT, Walborn DR, et al. Sanguinarine, a new antiplaque agent: Retention and plaque specificity. J. Am Dent Assoc. 1984 Mar;108(3):338- 341.
Review
For citations:
Torshin I.Yu., Gromova O.A., Tapilskaya N.I. Pharmacoinformation analysis of the molecules of the drug Klimaktoplan. Pharmacokinetics and Pharmacodynamics. 2018;(1):36-46. (In Russ.) https://doi.org/ 10.24411/2587-7836-2018-10005.
Views:
1219
Email this article 