Вовлечённость нейротрофинов в патогенез болезни Паркинсона

Болезнь Паркинсона — второе по распространённости нейродегенеративное заболевание, связанное с прогрессирующей гибелью дофаминер гических нейронов чёрной субстанции. К моменту появления первых симптомов заболевания и соответственно возможности его диагностики происходит потеря 50–60 % дофаминергических нейронов чёрной субстанции и снижение уровня дофамина в стриатуме на 70–80 %. Современная фармакотерапия болезни Паркинсона всё ещё остаётся преимущественно симптоматической и направлена на компенсацию дефицита дофамина в ЦНС. В связи с этим актуально создание новых противопаркинсонических средств, способных как замедлять нейродегенерацию, так и стимулировать нейрогенез. Белки семейства нейротрофинов являются эндогенными нейропротекторами, а также активируют репаративные процессы в повреждённой нервной ткани. В настоящем обзоре суммированы данные литературы о связи нейротрофинов с патогенезом болезни Паркинсона и об их антипаркинсоническом потенциале.

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