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Effect of various mineral additives on the state of excretory renal function and the level of glycemia in rats in experimental alloxan diabetes mellitus

https://doi.org/ 10.24411/2587-7836-2018-10002.

Abstract

On this study presents the results of the use of mineral additives salsamenteria of hypocol, selenopyran and Magne-Вб on alloxan model of diabetes in rats. A significant hypoglycemic effect of Magne B6 and selenopyran. It is revealed that all connections, especially hypocol and selenopyran have a beneficial effect on the excretory function of the kidneys in alloxan diabetes: reduce the severity of polyuria, glycosuria, and proteinuria (hypocol) and creatinine concentration in the blood (hypocol and selenopyran).

About the Authors

O. A. Nazarenko
Federal State Budgetary Educational Institution of Higher Education "Ivanovo State Medical Academy" of the Ministry of Healthcare of the Russian Federation
Russian Federation


O. A. Gromova
Federal Research Center "Computer Science and Control" of the Russian Academy of Sciences
Russian Federation


References

1. ВОЗ. Глобальный доклад по диабету (электронный ресурс). [WHO. Globalnyj doklad po diabetu [Internet] (In Russ).] URL: http://www.who. int/diabetes/global-report/ru/ Ссылка активна на 01.11.2017.

2. Шестакова М.В., Шамхалова, М.Ш. Диабетическая нефропатия: клиника, диагностика, лечение. М.: ФГУ Эндокринологический научный центр Росмедтехнологий. 2009.

3. Громова О.А., Гоголева И.В. Селен - впечатляющие итоги и перспективы применения // Трудный пациент. 2007;14(5):25-30.

4. Klotz LO, Krücke KD, Buchczyk DP, et al. Role of copper, zinc, selenium and tellurium in the cellular defence against oxidative and nitrosative stress. JNutr. 2003 May;133(5 Suppl 1):1448S-51S. DOI: 10.1093/jn/133.5.1448S

5. Штрыголь С.Ю., Бранчевский Л.Л. Действие адренергических агонистов и антагонистов на функцию почек и артериальное давление в зависимости от минерального состава рациона // Экспериментальная и клиническая фармакология. 1995;5:31-33.


Review

For citations:


Nazarenko O.A., Gromova O.A. Effect of various mineral additives on the state of excretory renal function and the level of glycemia in rats in experimental alloxan diabetes mellitus. Pharmacokinetics and Pharmacodynamics. 2018;(1):24-26. (In Russ.) https://doi.org/ 10.24411/2587-7836-2018-10002.

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ISSN 2587-7836 (Print)
ISSN 2686-8830 (Online)