Effect of a course of fabomotizole on atrial depolarization in rats with post-infarction chronic heart failure
https://doi.org/10.37489/2587-7836-2025-4-3-8
Abstract
Relevance. Post-infarction chronic heart failure contributes to the development of atrial fibrillation, the most common form of arrhythmia. The search for new drugs with pronounced antiarrhythmic activity is currently relevant.
Purpose of the study. To study the sequence of atrial epicardial depolarization in rats with post-infarction chronic heart failure after long-term administration of fabomotizole.
Methods. The sequence of atrial epicardial depolarization in rats with post-infarction chronic heart failure caused by anterior transmural myocardial infarction and sham-operated animals was studied using synchronous multichannel cardiac electrochronotopography after a course of fabomotizole administration.
Results. Post-infarction chronic heart failure provokes the appearance of an additional excitatory focus in the pulmonary vein lacunae of the left atrium, which is a predictor of atrial arrhythmogenicity. Fabomotizole suppresses an additional arrhythmogenic focus of excitation in the area where the pulmonary veins enter the left atrium, minimizing the risk of developing atrial tachyarrhythmias, including atrial fibrillation.
About the Authors
S. L. Smirnova
Federal Research Center “Komi Science Centre of the Ural Branch of the Russian Academy of Sciences”
Russian Federation
Russian Federation
Svetlana L. Smirnova — PhD, Cand. Sci. (Biology), Head of the Department of Comparative Cardiology
Syktyvkar
I. M. Roshchevskaya
Federal Research Center “Komi Science Centre of the Ural Branch of the Russian Academy of Sciences”
Russian Federation
Russian Federation
Irina M. Roshchevskaya — PhD, Dr. Sci. (Biology), Professor, Corresponding Member RAS, Chief Researcher of the department Comparative Cardiology FRC Komi SC UB RAS
Syktyvkar
I. B. Tsorin
Federal research center for innovator and emerging biomedical and pharmaceutical technologies
Russian Federation
Russian Federation
Iosif B. Tsorin — PhD, Dr. Sci. (Biology), Leading Researcher of Laboratory of Circulation Pharmacology
Moscow
S. A. Kryzhanovskii
Federal research center for innovator and emerging biomedical and pharmaceutical technologies
Russian Federation
Russian Federation
Sergey A. Kryzhanovskii — PhD, Dr. Sci. (Med.), Head of Laboratory of Circulation Pharmacology
Moscow
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Review
For citations:
Smirnova S.L., Roshchevskaya I.M., Tsorin I.B., Kryzhanovskii S.A. Effect of a course of fabomotizole on atrial depolarization in rats with post-infarction chronic heart failure. Pharmacokinetics and Pharmacodynamics. 2025;(4):3-8. (In Russ.) https://doi.org/10.37489/2587-7836-2025-4-3-8
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