Dimeric dipeptide mimetic the 1st loop of nerve growth factor of GK-6, which activates PI3K/AKT and MEK/MAPK/ERK, causes a neuronal type differentiation of PC12 cells
Abstract
Dimeric dipeptide mimetic 1st loop of NGF GK-6 (10-6M) activating as phosphatidylinozitol 3-kinase/Akt and mitogen-activated protein kinase MEK/MAPK/ERK) signaling cascades causes PC12 cell differentiation into neuron-like cells. At the same time dimeric dipeptide mimetic the 4th loop of NGF GK-2 (10-6M), which activates only phosphatidylinozitol 3-kinase/Akt, does not possess the differentiating effect.
About the Authors
T. A. Antipova
ФГБНУ «НИИ фармакологии имени В.В. Закусова»
Russian Federation
Russian Federation
S. V. Nikolaev
ФГБНУ «НИИ фармакологии имени В.В. Закусова»
Russian Federation
Russian Federation
A. V. Revishchin
Федеральное государственное бюджетное учреждение науки Институт биологии гена Российской академии наук
Russian Federation
Russian Federation
E. A. Savchenko
Федеральное государственное бюджетное учреждение науки Институт биологии гена Российской академии наук
Russian Federation
Russian Federation
G. V. Pavlova
Федеральное государственное бюджетное учреждение науки Институт биологии гена Российской академии наук
Russian Federation
Russian Federation
T. A. Gudasheva
ФГБНУ «НИИ фармакологии имени В.В. Закусова»
Russian Federation
Russian Federation
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Review
For citations:
Antipova T.A., Nikolaev S.V., Revishchin A.V., Savchenko E.A., Pavlova G.V., Gudasheva T.A. Dimeric dipeptide mimetic the 1st loop of nerve growth factor of GK-6, which activates PI3K/AKT and MEK/MAPK/ERK, causes a neuronal type differentiation of PC12 cells. Pharmacokinetics and Pharmacodynamics. 2017;(4):31-35. (In Russ.)
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