phkineticaФармакокинетика и ФармакодинамикаPharmacokinetics and Pharmacodynamics2587-78362686-8830ООО «Издательство ОКИ»phkinetica-42Research ArticleИССЛЕДОВАНИЯ МЕХАНИЗМА ДЕЙСТВИЯMECHANISM OF ACTION RESEARCHДимерный дипептидный миметик 1-й петли фактора роста нервов ГК-6, активирующий PI3K/AKT и МЕК/MAPK/ERK, вызывает дифференцировку клеток РС12 по нейрональному типуDimeric dipeptide mimetic the 1st loop of nerve growth factor of GK-6, which activates PI3K/AKT and MEK/MAPK/ERK, causes a neuronal type differentiation of PC12 cellsАнтиповаТатьяна АлексеевнаAntipovaT. A.zenina_tatyana@mail.ruНиколаевС. В.NikolaevS. V.noemail@neicon.ruРевищинА. В.RevishchinA. V.noemail@neicon.ruСавченкоЕ. А.SavchenkoE. A.noemail@neicon.ruПавловаГ. В.PavlovaG. V.noemail@neicon.ruГудашеваТ. А.GudashevaT. A.noemail@neicon.ruФГБНУ «НИИ фармакологии имени В.В. Закусова»Russian FederationФедеральное государственное бюджетное учреждение науки Институт биологии гена Российской академии наукRussian Federation201706112017043135Copyright © Антипова Т.А., Николаев С.В., Ревищин А.В., Савченко Е.А., Павлова Г.В., Гудашева Т.А., 20172017Антипова Т.А., Николаев С.В., Ревищин А.В., Савченко Е.А., Павлова Г.В., Гудашева Т.А.Antipova T.A., Nikolaev S.V., Revishchin A.V., Savchenko E.A., Pavlova G.V., Gudasheva T.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacokinetica.ru/jour/article/view/42

Димерный дипептидный миметик 1-й петли NGF ГК-6 (10-6М), активирующий как фосфатидилинозитол-З/АИ-киназный, так и митоген-активируемый протеинкиназный (MEK/MAPK/ERK) сигнальные каскады, вызывает дифференцировку клеток РС12 по нейрональному типу. В то же время димерный дипептидный миметик 4-й петли NGF ГК-2 (10-6М), активирующий только фос-фатидилинозитол-3/Akt- киназный путь, не обладает дифференцирующим действием.

Dimeric dipeptide mimetic 1st loop of NGF GK-6 (10-6M) activating as phosphatidylinozitol 3-kinase/Akt and mitogen-activated protein kinase MEK/MAPK/ERK) signaling cascades causes PC12 cell differentiation into neuron-like cells. At the same time dimeric dipeptide mimetic the 4th loop of NGF GK-2 (10-6M), which activates only phosphatidylinozitol 3-kinase/Akt, does not possess the differentiating effect.

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The authors declare that there are no conflicts of interest present.