The effectiveness of lithium ascorbate on chronic alcohol intoxication model
Abstract
The alcohol leads to deviant behavior in animals, increases aggression and irreversible degenerative changes in the liver and in the central nervous system. Lithium ascorbate in dose of 5 mg/kg, as well as higher doses (10 and 30 mg/kg), activates adaptive mechanisms normalizing behavioral responses in the tests «open field» and «elevated plus-maze». Histological analysis showed that lithium ascorbate minimize ischemic damage of neurocytes to a reversible state. In general, the use of lithium ascorbate contributes to relief of withdrawal symptoms, inhibited the occurrence of seizures and contributed to preservation of the function of the central nervous system in the model of chronic alcohol intoxication.
About the Authors
K. V. Ostrenko
FGBNU «Institute of Physiology, Biochemistry and Nutrition of Animals»
Russian Federation
Russian Federation
O. A. Gromova
«Ivanovo State Medical Academy»
Russian Federation
Russian Federation
I. S. Sardaryan
FFSBI HPE «Saint Petersburg State Pediatric Medical University» of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
V. I. Demidov
«Ivanovo State Medical Academy»
Russian Federation
Russian Federation
N. Yu. Zhidomorov
«Ivanovo State Medical Academy»
Russian Federation
Russian Federation
I. Yu. Torshin
Moscow Institute of Physics and Technology (State University)
Russian Federation
Russian Federation
A. V. Pronin
«Ivanovo State Medical Academy»
Russian Federation
Russian Federation
V. A. Krivonogov
«Ivanovo State Medical Academy»
Russian Federation
Russian Federation
Yu. V. Karpunina
«Ivanovo State Medical Academy»
Russian Federation
Russian Federation
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Review
For citations:
Ostrenko K.V., Gromova O.A., Sardaryan I.S., Demidov V.I., Zhidomorov N.Yu., Torshin I.Yu., Pronin A.V., Krivonogov V.A., Karpunina Yu.V. The effectiveness of lithium ascorbate on chronic alcohol intoxication model. Pharmacokinetics and Pharmacodynamics. 2017;(1):11-21. (In Russ.)
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