Effect of GK-1 NGF Loop 4 Dipeptide Mimetic on tumor growth and metastasis of Lewis lung carcinoma in experiment on male C57BL/6 mice
https://doi.org/10.37489/2587-7836-2023-1-45-50
Abstract
Article describes results of study of antitumor and antimetastatic action of dipeptide mimetic of the nerve growth factor amide N-monosuccinyl-L-glutamyl-L-lysine (compound GK-1) in comparison with gemcitabine. Two injections of gemcitabine in total dose of 100 mg/kg resulted in significant tumor growth inhibition by 60–61% on 7th, 9th and 15th days of tumor development. Course administration of GK-1 in doses of 10 mk/kg from 2nd to 15th day of tumor development resulted in significant tumor growth inhibition by 57,8 %. Metastasis inhibition index (MII) of gemcitabine was 75,8 %. MII of GK-1 in doses of 10 mg/kg or 30 mg/kg was 44,9 % and 47,7 % accordingly. It was shown that GK-1 in studied range of doses exerts antimetastatic activity.
About the Authors
L. P. Kovalenko
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
Kovalenko Larisa P., Dr. Sci. (Biology), leading researcher of department of drug toxicology
Moscow
R. V. Zhurikov
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
Zhurikov Ruslan V., Junior researcher of department of drug toxicology
Moscow
P. Yu. Povarnina
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
Povarnina Polina Yu.,PhD, Cand. Sci. (Biology), senior researcher of the Department of Chemistry of Medicines
Moscow
A. V. Tarasiuk
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
Tarasiuk Aleksey V., Senior researcher of the Department of Chemistry of Medicines
Moscow
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Review
For citations:
Kovalenko L.P., Zhurikov R.V., Povarnina P.Yu., Tarasiuk A.V. Effect of GK-1 NGF Loop 4 Dipeptide Mimetic on tumor growth and metastasis of Lewis lung carcinoma in experiment on male C57BL/6 mice. Pharmacokinetics and Pharmacodynamics. 2023;(1):45-50. (In Russ.) https://doi.org/10.37489/2587-7836-2023-1-45-50
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