Disribution kinetics of cardioprotector ALM-802 in rat organs and tissues
https://doi.org/10.37489/2587-7836-2022-2-17-22
Abstract
The distribution kinetics of a compound with cardioprotective activity, N1-(2,3,4-trimethoxybenzyl)-N2-{2-[(2,3,4-trimethoxybenzyl)amino] ethyl}-1,2-ethanediamine (ALM-802) in rat tissues and organs after single intragastric administration at a dose of 100 mg/kg. The values of ALM-802 tissue availability were determined. Tissue availability of ALM-802 falls in a row: kidneys→liver→heart→spleen→skeletal muscle→brain (129.3; 27.2; 20.9; 15.3; 5.9 and 0.3, respectively). It was found that ALM-802 is excreted from the body rather slowly: kel values ranged from 0.0252 to 0.0885 h–1, MRT values were 7.6–59.3 h.
Supporting agencies: The work was carried out within the framework of State task No. FGFG-2022-0003 «Study of pathophysiological mechanisms of the formation of alcohol-related heart pathology and search for molecular targets for pharmacological correction of the revealed disorders».
About the Authors
O. Yu. Kravtsova
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
Kravtsova Oxana Yu., PhD of Biological sciences, researcher scientist of pharmacokinetics laboratory. SPIN code: 1733-2330
Moscow
G. B. Kolyvanov
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
Kolyvanov Gennadiy B., Dr. Sci. in Biology, Leading researcher of the laboratory of pharmacokinetics. SPIN code: 2538-8639
Moscow
A. A. Litvin
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
Litvin Alexander A., Dr. Sci. in Biology, Leading researcher of the laboratory of pharmacokinetics. SPIN code: 6193-5770
Moscow
P. O. Bochkov
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
Bochkov Pavel O., PhD in Biology, Senior Research Officer of laboratory pharmacokinetics. SPIN code: 5576-8174
Moscow
V. P. Zherdev
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
Zherdev Vladimir P., Dr. Sci. in Medicine, professor, Head of laboratory pharmacokinetics. SPIN code: 2213-9592
Moscow
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Review
For citations:
Kravtsova O.Yu., Kolyvanov G.B., Litvin A.A., Bochkov P.O., Zherdev V.P. Disribution kinetics of cardioprotector ALM-802 in rat organs and tissues. Pharmacokinetics and Pharmacodynamics. 2022;(2):17-22. (In Russ.) https://doi.org/10.37489/2587-7836-2022-2-17-22
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