Dynamics of the cardioelectric field of rats under chronic exposure to doxorubicin during atrial depolarization
https://doi.org/10.37489/2587-7836-2021-3-31-35
Abstract
The aim of the work is non-invasive identification of the features of the initial atrial activity by the dynamics of the cardioelectric field on the surface of the chest of experimental animals under chronic exposure to doxorubicin. Materials and methods. The distribution and dynamics of changes in cardioelectric potentials on the surface of the chest of rats under chronic exposure to doxorubicin during the period of initial atrial activity were investigated. Doxorubicin was administered intraperitoneally 1.5 mg/kg once a week for a month. The cumulative dose was 6 mg/kg animal weight. Results. It has been shown that chronic exposure to doxysubicin leads to changes in the positional dynamics of positive and negative cardiopotentials cardioelectric field of heart on the chest surface during the ascending and descending P-wave on the ECG in the II limb leads. It is observed significantly earlier the beginning of cardioelectric field formation, characteristic of atrial depolarization, on the body surface, the beginning, the peak and the end of the P-wave on the ECG in the II limb leads compared to the initial state. Conclusion. Chronic exposure to doxorubicin causes significant changes in the initial atrial activity, which leads to a significant change in the corresponding period of atrial depolarization in the dynamics of the cardioelectric field on the surface of the thorax of animals.
About the Authors
S. L. Smirnova
Federal Research Center "Komi Science Centre of the Ural Branch of the Russian Academy of Sciences"
Russian Federation
Russian Federation
Smirnova Svetlana L. - PhD in Biology, Head of the department
Syktyvkar
O. V. Suslonova
Federal Research Center "Komi Science Centre of the Ural Branch of the Russian Academy of Sciences"
Russian Federation
Russian Federation
Suslonova Olga V. - Research associate
Syktyvkar
I. M. Roshchevskaya
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
Roshchevskaya Irina M. - Dr. Sci. (Biol.), Corresponding Member RAS, Chief Researcher of the Laboratory of Pharmacological Screening
Moscow
References
1. Luu AZ, Chowdhury BB, Al-Omran M et al. Role of endothelium in doxorubicin-induced cardiomyopathy. JACC Basic Transl Sci. 2018;3(6):861–870. DOI:10.1016/j.jacbts.2018.06.005.
2. Chaulin AM, Duplyakov DV. Arrhythmogenic effects of doxorubicin. Complex Issues of Cardiovascular Diseases. 2020;9(3):69–78 (In Russ). DOI:10.17802/2306-1278-2020-9-3-69-80.
3. Aygun H, Gul SS. Cardioprotective effect of melatonin and agomelatine on doxorubicin-induced cardiotoxicity in a rat model: an electrocardiographic, scintigraphic and biochemical study. Bratisl Lek Listy. 2019;120(4):249–255. DOI:10.4149/BLL_2019_045.
4. Sonawane VK, Mahajian UB, Shinde SD et al. A chemosensitizer drug: disulfiram prevents doxorubicin-induced cardiac dysfunction and oxidative stress in rats. Cardiovasc Toxicol. 2018;18(5):459–470. DOI:10.1007/s12012-018-9458-y.
5. Jafarinezhad Z, Rafati A, Ketabchi F et al. Cardioprotective effects of curcumin and carvacrol in doxorubicin-treated rats: Stereological study. Food Sci Nutr. 2019;7(11):3581–3588. DOI:10.1002/fsn3.1210.
6. Yaylali YT, Saricopur A, Yurtdas M et al. Atrial function in patients with breast cancer after treatment with anthracyclines. Arq Bras Cardiol. 2016;107(5):411–419. DOI:10.5935/abc.20160146.
7. Smirnova SL, Suslonova OV, Roshchevskaya IM. Non-invasive detection of arrhythmogenic foci of atria by using the cardioelectric field on the surface of the body during experimental pulmonary hypertension. Journal of Arrhythmology. 2020;1(99): 63–69. (In Russ). DOI:10.35336/VA-2020-1-63-69.
8. Smirnova SL, Suslonova OV, Roshchevskaya IM. Cardioelectric field on the body surface during atrial depolarization in rats with spontaneous arterial hypertension. Practical Medicine. 2018;1(112): 61–64. (In Russ).
9. Smirnova SL, Roshchevskaya IM, Roshchevsky MP et al. Atria depolarization in rats with alcoholic сardiomyopathy. Doklady biological sciences. 2018;479(1):41–43. (In Russ). DOI:10.7868/S0869565218010231.
10. Smirnova SL, Roshchevskaya IM, Tsorin IB, Stolyaruk VN, Vititnova MB, Kolik LG, Kryzhanovskii SA. Cardioelectric field on the body surface during atrial depolarization in rats with alcoholic cardiomyopathy. Farmakokinetika i farmakodinamika. 2019;(2):17–22. (In Russ). DOI:10.24411/2588-0519-2019-10041.
Review
For citations:
Smirnova S.L., Suslonova O.V., Roshchevskaya I.M. Dynamics of the cardioelectric field of rats under chronic exposure to doxorubicin during atrial depolarization. Pharmacokinetics and Pharmacodynamics. 2021;(3):31-35. (In Russ.) https://doi.org/10.37489/2587-7836-2021-3-31-35
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