Gender differences in the formation of the epileptic system in male and female rats depending on the stage of the estrous cycle on the model of focal cobalt epilepsy
https://doi.org/10.37489/2587-7836-2021-3-26-30
Abstract
In this work, the features of the formation of the epileptic system in male and female rats, depending on the stages of the estrous cycle, were studied on the model of focal cobalt epilepsy. It was found that in male rats at the stable stage of the first stage of development of the epileptic system, Epi activity (the number and duration of discharges per minute) is most pronounced in the contralateral and ipsilateral cortex, and in female rats, the leading brain structures involved in the generation of EpA depend on the phases of the estrous cycle. In the diestrus2 phase, in females, the leading structure generating EpA, as in males, is the contralateral cortex, and in the proestrus and estrus phases, which are characterized by a high content of sex hormones, in females there is a significant predominance of EpA in the lateral hypothalamus and dorsal hippocampus.
Keywords
Supporting agencies: This work was carried out as part of the state assignment (project No. 0521-2019-0007) "Development of treatments for epilepsy, Parkinson's disease and autism based on new data on the pathogenesis of diseases".
About the Authors
T. A. Voronina
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
Voronina Tatiana A. - Dr. Sci. (Med.), professor, Head of the Laboratory of Psychopharmacology
Moscow
S. A. Litvinova
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
Litvinova Svetlana A. - PhD in Biology, Leading researcher Laboratory of Psychopharmacology
Moscow
Y. B. Filatova
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
Filatova Julia B. - Laboratory Research Assistant Laboratory of psychopharmacology
Moscow
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Review
For citations:
Voronina T.A., Litvinova S.A., Filatova Y.B. Gender differences in the formation of the epileptic system in male and female rats depending on the stage of the estrous cycle on the model of focal cobalt epilepsy. Pharmacokinetics and Pharmacodynamics. 2021;(3):26-30. (In Russ.) https://doi.org/10.37489/2587-7836-2021-3-26-30
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