Antiarrhythmic properties of N-Deacetyllappaconitine Hydrochloride
https://doi.org/10.37489/2587-7836-2021-2-19-24
Abstract
The aim of the investigation was the research of the N-deacetyllappaconitine hydrochloride antiarrhythmic properties. It was found that the studied substance was effective on the cardiac arrhythmias model caused by aconitine hydrochloride, but does not act on the models of calciume chlorideinduced arrhythmias and reperfusion ventricular fibrillation. The studied compound is less toxic than the comparison drug lappaconitine hydrobromide and acts in lower doses on the aconitine model of arrhythmias. N-Deacetyllappaconitine hydrochloride appears to be a Class I antiarrhythmic agent according to the Vaughan Williams classification.
About the Authors
S. A. Kryzhanovskii
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
Kryzhanovskii Sergey A. - Dr. Sci. (Med.), Head of laboratory of pharmacological
screening
SPIN code: 6596-4865
Moscow
M. S. Yunusov
Ufa Institute of Chemistry UFRC RAS
Russian Federation
Russian Federation
Yunusov Marat S. - D. Sci. in Chemistry, academician of RAS, Chief researcher
SPIN code: 4308-3287
Moscow
I. B. Tsorin
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
Tsorin Iosif B. - D. Sci. in Biology, Leading researcher of laboratory
of pharmacological screening
Moscow
V. V. Barchukov
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
Barchukov Vladimir V. - Research scientist of laboratory of pharmacological
screening
SPIN code: 6743-4280
Moscow
E. I. Barchukova
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
Barchukova Elena I. - Research Assistant of laboratory of pharmacological screening
Moscow
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Review
For citations:
Kryzhanovskii S.A., Yunusov M.S., Tsorin I.B., Barchukov V.V., Barchukova E.I. Antiarrhythmic properties of N-Deacetyllappaconitine Hydrochloride. Pharmacokinetics and Pharmacodynamics. 2021;(2):19-24. (In Russ.) https://doi.org/10.37489/2587-7836-2021-2-19-24
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