The acute toxicity study GIZH-290 in mice
S. V. Alekseeva,
A. V. Sorokina,
A. V. Volkova,
V. V. Zabrodina,
I. A. Miroshkina,
K. S. Kachalov,
I. V. Alekseev,
A. D. Zaharov https://doi.org/10.37489/2587-7836-2020-4-41-46
Abstract
Acute toxicity testing is a commonly accepted procedure for preclinical testing of the safety of potential drugs. The compound GIZh-290, which is a derivative of 4-phenylpyrrolidone– 2,6 - dimethylanilide (2-oxo-4-phenylpyrrolidine-1-yl) acetic acid and has a nootropic and anticonvulsant effect, was studied. The results obtained after a single oral and intraperitoneal administration to mice allow us to attribute GIZH-290 to the 4th class of toxicity – "lowtoxic substances". The study revealed the neurotoxic effects of GIZH-290, which may be due to the main pharmacological activity of the compound used in sublethal doses.
About the Authors
S. V. Alekseeva
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Alekseeva Svetlana V. Senior Research Officer of laboratory of drug toxicolog
Moscow
SPIN code: 8985-3418
A. V. Sorokina
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Sorokina Aleksandra V. – PhD in Biology, Leading researcher of the laboratory of drug toxicology
Moscow
A. V. Volkova
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Volkova Anna V. – Senior Research Officer of laboratory of psychopharmacology
Moscow
V. V. Zabrodina
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Zabrodina Victoria V. – PhD in Biology, Research scientist of the laboratory of drug toxicology
Moscow
SPIN code: 8473-6920
I. A. Miroshkina
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Miroshkina Irina A. – Research scientist of the laboratory of drug toxicology
Moscow
SPIN code: 4697-7938
K. S. Kachalov
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Kachalov Kirill S. – Engineer of the 1st category of the laboratory of drug toxicology FSBI «Zakusov Institute of Pharmacology»; student of the pharmaceutical faculty of the Moscow medical university «Reaviz»
Moscow
SPIN code: 2992-6789
I. V. Alekseev
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Alekseev Ivan V. – Engineer of the 1st category of the Laboratory of Pharmacology of mutagenesis FSBI «Zakusov Institute of Pharmacology»; student of the faculty of pharmacy Moscow Medical University «Reaviz»
Moscow
SPIN code: 9757-6210
A. D. Zaharov
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Zakharov Aleksei D. Junior researcher of the laboratory of drug toxicology
Moscow
SPIN code: 9013-6228
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Review
For citations:
Alekseeva S.V., Sorokina A.V., Volkova A.V., Zabrodina V.V., Miroshkina I.A., Kachalov K.S., Alekseev I.V., Zaharov A.D. The acute toxicity study GIZH-290 in mice. Pharmacokinetics and Pharmacodynamics. 2020;(4):41-47. (In Russ.) https://doi.org/10.37489/2587-7836-2020-4-41-46
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