Study the subchronic toxicity of the drug Dantinorm Baby
A. V. Sorokina,
S. V. Alekseeva,
I. A. Miroshkina,
K. S. Kachalov,
A. D. Zaharov,
I. V. Alekseev,
A. S. Lapizkaya https://doi.org/10.37489/2587-7836-2020-3-52-60
Abstract
Presents results of a study of subchronic toxicity of homeopathic drug Dantinorm Baby in finished dosage form. The drug in the form of a ready solution was administered daily orally for one month to outbred rats Infanta and chinchilla rabbits at a dose of 0.3 ml/kg, corresponding to the therapeutic, and 3 ml/kg, exceeding the therapeutic dose 10 times. Clinical, laboratory and histopathological studies performed in accordance with the General Protocol, showed no toxic effects of homeopathic preparation of Dantinorm Baby. The totality of the obtained data of the subchronic experiment indicates that there are no obstacles to the clinical study of the drug Dantinorm Baby in the range of therapeutic dosages.
About the Authors
A. V. Sorokina
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Sorokina Aleksandra V., PhD in Biology, Leading researcher of the laboratory of drug toxicology
S. V. Alekseeva
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Alekseeva Svetlana V., Leading researcher of laboratory of drug toxicolog
SPIN code: 8985-3418
I. A. Miroshkina
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Miroshkina Irina A., Research scientist of the laboratory of drug toxicology
SPIN code: 4697-7938
K. S. Kachalov
FSBI «Zakusov Institute of Pharmacology»; Moscow medical university «Reaviz»
Russian Federation
Russian Federation
Kachalov Kirill S., Engineer of the 1st category of the laboratory of
drug toxicology; student of the pharmaceutical faculty
SPIN code: 2992-6789
A. D. Zaharov
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Zakharov Aleksei D., Junior researcher of the laboratory of drug toxicolog
SPIN code: 9013-6228
I. V. Alekseev
FSBI «Zakusov Institute of Pharmacology»; Moscow medical university «Reaviz»
Russian Federation
Russian Federation
Alekseev Ivan V., Engineer of the 1st category of the Laboratory
of Pharmacology of mutagenesis; student of the faculty of pharmacy
SPIN code: 9757-6210
A. S. Lapizkaya
Gabricheysky Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
SPIN code: 7966-8750
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For citations:
Sorokina A.V., Alekseeva S.V., Miroshkina I.A., Kachalov K.S., Zaharov A.D., Alekseev I.V., Lapizkaya A.S. Study the subchronic toxicity of the drug Dantinorm Baby. Pharmacokinetics and Pharmacodynamics. 2020;(3):52-60. (In Russ.) https://doi.org/10.37489/2587-7836-2020-3-52-60
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