Comparative study of the neuroprotective activity of lithium compounds and their effect on the course of experimental alloxan diabetes mellitus in rats
https://doi.org/10.37489/2587-7836-2020-3-40-47
Abstract
A comparative study of the effects of an inorganic lithium salt (lithium carbonate) and an organic lithium salt (lithium ascorbate) on a model of alloxan diabetes mellitus was conducted. The use of lithium ascorbate for a month in experimental alloxan diabetes mellitus facilitates its course – the survival rate of animals increases, the level of glycemia decreases (especially when administered at a dose of 10 mg/kg). Morphometric analysis showed that lithium ascorbate in alloxan diabetes has a neuroprotective effect, which is manifested in a decrease in toxic damage to neurocytes with an increase in the number of cells with reversible changes and intact neurons. Lithium carbonate at doses of 5 and 10 mg / kg was not effective.
About the Authors
O. A. Nazarenko
FSBEI HE IvSMA MOН Russia
Russian Federation
Russian Federation
Nazarenko Olga A. , PhD in Medicine, associate Professor of the
Department of Pharmacology
V. I. Demidov
FSBEI HE IvSMA MOН Russia
Russian Federation
Russian Federation
Demidov Vadim I., PhD in Medicine, associate Professor, Head of the Department of Pathological Anatomy
O. A. Gromova
Federal Research Center "Computer Science and Control" of the Russian Academy of Sciences; Big Data Storage and Analysis Center FSEI HPE Lomonosov Moscow State University
Russian Federation
Russian Federation
Gromova Olga A., Dr. Sci. (Med.), Professor
SPIN code: 6317-9833
E. L. Aleksakhina
FSBEI HE IvSMA MOН Russia
Russian Federation
Russian Federation
Aleksakhina Elena L., Candidate of Chemical Sciences, associate Professor of the Department of Chemistry, Physics,
Mathematics
SPIN code: 2568-6370
I. Yu. Torshin
Federal Research Center "Computer Science and Control" of the Russian Academy of Sciences; Big Data Storage and Analysis Center FSEI HPE Lomonosov Moscow State University
Russian Federation
Russian Federation
Torshin Ivan Yu. , Candidate of Chemical Sciences, Senior researcher
SPIN code: 1375-1114
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Review
For citations:
Nazarenko O.A., Demidov V.I., Gromova O.A., Aleksakhina E.L., Torshin I.Yu. Comparative study of the neuroprotective activity of lithium compounds and their effect on the course of experimental alloxan diabetes mellitus in rats. Pharmacokinetics and Pharmacodynamics. 2020;(3):40-47. (In Russ.) https://doi.org/10.37489/2587-7836-2020-3-40-47
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