The pharmacokinetics of the injectable dosage form of GK-2 in rabbits
R. V. Shevchenko,
A. A. Litvin,
G. B. Kolyvanov,
P. O. Bochkov,
O. G. Gribakina,
A. A. Novitskiy,
V. P. Zherdev https://doi.org/10.37489/2587-7836-2020-2-17-21
Abstract
The pharmacokinetics of the nerve growth factor mimetic GK-2 (dimeric dipeptide mimetic of the 4-th loop NGF, a derivative of fluoro-substituted 5-[2-(5-fluoropyrid-3-yl) -ethyl)]-2,8-dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole) in rabbits after a single intravenous injection of an injectable dosage form at dose 24 mg (7,8-8,7 mg/kg). GK-2 concentrations in the blood plasma were determined by high-performance liquid chromatography with massspectrometric detection. GK-2 can be attributed to "short-lived" drugs, since the half-life from the rabbits blood plasma was 0.9±0.1 h.
About the Authors
R. V. Shevchenko
FSBI «Zakusov Research Institute of Pharmacology»
Russian Federation
Russian Federation
Shevchenko Roman V. – PhD in Medicine, Research Officer of laboratory pharmacokinetics. SPIN code: 1844-6202
Moscow
A. A. Litvin
FSBI «Zakusov Research Institute of Pharmacology»
Russian Federation
Russian Federation
Litvin Alexander A. – D. Sci. in Biology, leading researcher of the laboratory of pharmacokinetics. SPIN code: 6193-5770
Moscow
G. B. Kolyvanov
FSBI «Zakusov Research Institute of Pharmacology»
Russian Federation
Russian Federation
Kolyvanov Gennadiy B. – D. Sci. in Biology, Leading researcher of the laboratory of pharmacokinetics. SPIN code: 2538-8639
Moscow
P. O. Bochkov
FSBI «Zakusov Research Institute of Pharmacology»
Russian Federation
Russian Federation
Bochkov Pavel O. – PhD in Biology, Senior Research Officer of laboratory pharmacokinetics. SPIN code: 5576-8174
Moscow
O. G. Gribakina
FSBI «Zakusov Research Institute of Pharmacology»
Russian Federation
Russian Federation
Gribakina Oxana G. – PhD in Biology, Research Officer of laboratory pharmacokinetics. SPIN code: 6266-8161
Moscow
A. A. Novitskiy
FSBI «Zakusov Research Institute of Pharmacology»
Russian Federation
Russian Federation
Novitskiy Alexander A. – Research Officer of laboratory pharmacokinetics
Moscow
V. P. Zherdev
FSBI «Zakusov Research Institute of Pharmacology»
Russian Federation
Russian Federation
Zherdev Vladimir – D. Sci. in Medicine, professor, Head of laboratory pharmacokinetics. SPIN code: 2213-9592
Moscow
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Review
For citations:
Shevchenko R.V., Litvin A.A., Kolyvanov G.B., Bochkov P.O., Gribakina O.G., Novitskiy A.A., Zherdev V.P. The pharmacokinetics of the injectable dosage form of GK-2 in rabbits. Pharmacokinetics and Pharmacodynamics. 2020;(2):17-21. (In Russ.) https://doi.org/10.37489/2587-7836-2020-2-17-21
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