Preview

Pharmacokinetics and Pharmacodynamics

Advanced search

The effects of cycloprolylglycine and its analogues on brain monoaminergic systems in BALB/c mice

https://doi.org/10.37489/2587-7836-2020-1-3-10

Abstract

Effects of chronic cycloprolylglycine (CPG) and its analogues GZK-001 and GZK-002 treatment at the doses 1 and 2 mg/kg on levels of monoamines and their metabolites in BALB/c mice brain were determined by HPLC. Neurochemical data demonstrated that antidepressant-like effects of the peptides are mediated by an increase in NA and decrease in DA content in frontal cortex. Alterations in striatal monoamine metabolism were observed predominantly after CPG's analogues treatment: the concentration of DA was increased, although its rate of turnover was diminished. In hippocampus more active was CPG: the levels of NE, DA, 5-HT, and its metabolite 5-HIAA were decreased. GZK-001 (1 mg/kg) caused a decrease in the concentration of DA and 5-HIAA. The present results suggest that antidepressant-like effects of CPG and its analogues are associated with DA, NE, and 5-HT systems.

About the Authors

A. A. Abdullina
FSBI Zakusov Institute of Pharmacology
Russian Federation

Abdullina Аliya Corresponding author - Junior Researcher, Laboratory of radioisotope research methods, SPIN code: 9781-1554.

Moscow


E. V. Vasileva
FSBI Zakusov Institute of Pharmacology
Russian Federation

Vasileva Ekaterina - PhD in Biology, Senior Research Scientist, Laboratory of radioisotope research methods, SPIN code: 1054-4872.

Moscow



V. S. Kudrin
FSBI Zakusov Institute of Pharmacology
Russian Federation

Kudrin Vladimir - PhD in Medicine, Head of Laboratory of Neurochemical Pharmacology, SPIN code: 3986-3262.

Moscow



V. B Narkevich
FSBI Zakusov Institute of Pharmacology
Russian Federation

Narkevich Victor - PhD in Medicine, Senior Research Scientist, Laboratory of Neurochemical Pharmacology.

Moscow


T. A. Gudasheva
FSBI Zakusov Institute of Pharmacology
Russian Federation

Gudasheva Tatiana - D. Sci. in Biology, professor, corresponding member of the RAS, Head of Medicinal chemistry department, SPIN code: 4970-0006.

Moscow


K. N. Kolyasnikova
FSBI Zakusov Institute of Pharmacology
Russian Federation

Kolyasnikova Ksenia - PhD in Biology, Research Scientist, Laboratory of peptide bioregulators, Department of medicinal chemistry, SPIN code: 5682-2035.

Moscow



G. I. Kovalev
FSBI Zakusov Institute of Pharmacology
Russian Federation

Kovalev Georgy - D. Sci. in Medicine, professor, Head of the Laboratory of radioisotope research methods, SPIN code: 8461-8814.

Moscow



References

1. Gudasheva TA, Konstantinopol'skii MA, Ostrovskaya RU, Seredenin S.B. Anxiolytic activity of endogenous nootropic dipeptide cycloprolylglycine in elevated plus-maze test. Bulletin of experimental biology and medicine. 2001;131(5):547—550. (In Russ).

2. Seredenin SB, Gudasheva TA, Boiko SS, et al. Endogenous Dipeptide Cycloprolylglycine Shows Selective Anxiolytic Activity in Animals with Manifest Fear Reaction. Bulletin of Experimental Biology and Medicine. 2002;133(4):360—362.

3. Gudasheva TA, Ostrovskaya RU, Trofimov SS, et al. New endogenous dipeptide cycloprolyl-glycine is similar to piracetam by its mnemotropic selectivity. Bulletin of experimental biology and medicine. 1999; 128(4):411—413. (In Russ).

4. Kolyasnikova KN, Gudasheva TA, Nazarova GA, et al. Similarity of cycloprolylglycine to piracetam in antihypoxic and neuroprotective effects. Russian Journal of Experimental and Clinical Pharmacology. 2012;75(9):3—6. (In Russ).

5. Povarnina P.Yu., Kolyasnikova K.N., Nikolaev S.V. et al. Nejropeptid cikloprolilglicin proyavlyaet nejroprotektivnuyu aktivnost' pri sistemnom vvedenii na modeli nepolnoj global'noj ishemii u krys i v usloviyah glutamatnoj nejrotoksichnosti in vitro. Byulleten' eksperimental’nojbiologiiimediciny. 2015;160(11):600—603. (In Russ).

6. Kovalev G.I., Abdullina A.A., Vasil'eva E.V Antidepressant-Like Properties of Cycloprolylglycine. Eksperimental'naya i klinicheskaya farmakologiya. 2018;81(10):76—79. (In Russ). DOI: 10.30906/0869-2092-2018-81-11-3-6

7. Abdullina A.A., Vasil'eva E.V., Kondrakhin E.A. Antidepressant-Like Effects of Cycloprolylglycine Analogs and the Involvement of Serotonin-, Glutamate-, and GABA-Receptors in Their Mechanisms. Eksperimental'naya i klinicheskaya farmakologiya. 2019;82(6): 8-15. (In Russ). DOI: 10.30906/0869-2092-2019-82-6-8-15

8. Gudasheva TA., Koliasnikova K.N., Seredenin S.B., Grigoriev W, Zamoyski VL. Neuropeptide cycloprolylglycine is an endogenous positive modulator of AMPA receptors. Doklady Biochemistry and Biophysics. 2016;471(1):387—389. (In Russ).

9. Gudasheva TA, Kolyasnikova KN, Antipova TA, Seredenin S.B. Neuropeptide cycloprolylglycine increases the levels of brain-derived neurotrophic factor in neuronal cells. Doklady Akademii nauk. 2016;469(4):492—495. (In Russ). DOI: 0.7868/S0869565216220254

10. Abdullina A.A., Vasilyeva E.V., Kondrakhin E.A., Kovalev G.I. Participation of Serotonin, Glutamate, and GABA Receptorsin the Manifestation of Antidepressive-Like Effect of Cycloprolylglycine. Nejrohimiya. 2019;36(3):218—225. (In Russ). DOI: 10.1134/S1027813319030026

11. Narkevich V.B., Ovchinnikova I.P., Klodt P.M., Kudrin V.S. The effects of himantane and cycloprolylglycine on the enzymatic linkage of monoamine synthesis in the rat brain. Nejrohimiya. 2012;29(4): 1-7. (In Russ).

12. Glowinski J, Iversen LL. Regional studies of catecholamines in the rat brain. Journal of Neurochemistry.1966;13(8):655-669. DOI: 10.1111/j.1471-4159.1966.tb09873.x

13. Kudrin V.S., Nadorova A.V., Narkevich V.B., Kolik L.G. An Analysis of the Behavioral and Neurochemical Effects of Himantane on the Dynamics of the Ethanol-Induced Hyperlocomotor Response in DBA/2 Mice. Nejrohimiya. 2018;35(1):62—69. (In Russ). DOI: 10.7868/S1027813318010065

14. Lavergne F, Jay TM. A new strategy for antidepressant prescription. Frontiers in neuroscience. 2010;4:192. DOI:10.3389/fnins.2010.00192

15. Arias-Carrión O, Stamelou M, Murillo-Rodriguez E, et al. Dopaminergic reward system: a short integrative review. International Archives of Medicine. 2010;(3):24. DOI: 10.1186/1755-7682-3-24

16. Escalona R, Fawcett J. Pramipexole in Treatment Resistant-Depression, Possible Role of Inflammatory Cytokines. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology. 2017;42(1):363. DOI:10.1038/npp.2016.217


Review

For citations:


Abdullina A.A., Vasileva E.V., Kudrin V.S., Narkevich V.B., Gudasheva T.A., Kolyasnikova K.N., Kovalev G.I. The effects of cycloprolylglycine and its analogues on brain monoaminergic systems in BALB/c mice. Pharmacokinetics and Pharmacodynamics. 2020;(1):3-10. (In Russ.) https://doi.org/10.37489/2587-7836-2020-1-3-10

Views: 1672


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2587-7836 (Print)
ISSN 2686-8830 (Online)