Antidepressant-like activity of the dipeptide mimetic of brain-derived neurotrophic factor GSB-106 in Porsolt test after intraperitoneal sub-chronically and chronically treatment in mice
https://doi.org/10.37489/2587-7836-2019-4-24-27
Abstract
The present work was to study the GSB-106 effect on the immobility behavior of mice Balb/c in the Porsolt test. GSB-106 was administered sub-chronically and chronically intraperitoneal in dose 1 mg/kg. GSB-106 administration significantly decreased immobility time in mice by 1.2 times after 4 days, by 1.3 times after 14 days and 1.2 times after 21 days’ injections. Thus, the dependence of the GSB-106 effect-time administration in the Porsolt test was not established.
About the Authors
A. V. Tallerova
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Tallerova Anna, SPIN code: 2826-2687, Candidate of Biologicall Sciences, Senior Researcher, the laboratory of peptide bioregulators, Moscow
Russian Federation
Tallerova Anna, SPIN code: 2826-2687, Candidate of Biologicall Sciences, Senior Researcher, the laboratory of peptide bioregulators, Moscow
P. Y. Povarnina
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Povarnina Polina, SPIN code: 5498-6724, Candidate of Biologicall Sciences, Senior Researcher, Laboratory of Peptide Bioregulators, Moscow
S. V. Minaev
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Minaev Sergey, Candidate of Pharmaceutical Sciences, Head of the experimental and technological Department, Moscow
T. A. Gudasheva
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Gudasheva Tatiana, SPIN code: 4970-0006, Doctor of Biological Sciences, professor, RAS corresponding member, Head of medicinal chemistry department, Moscow
S. B. Seredenin
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
Seredenin Sergey, SPIN code: 3896-4655, Doctor of Medical Sciences, professor, academician of RAS, Head of the laboratory of pharmacological genetics, Moscow
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Review
For citations:
Tallerova A.V., Povarnina P.Y., Minaev S.V., Gudasheva T.A., Seredenin S.B. Antidepressant-like activity of the dipeptide mimetic of brain-derived neurotrophic factor GSB-106 in Porsolt test after intraperitoneal sub-chronically and chronically treatment in mice. Pharmacokinetics and Pharmacodynamics. 2019;(4):24-27. (In Russ.) https://doi.org/10.37489/2587-7836-2019-4-24-27
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