Correction by Laennec of chronic iron overload liver, kidneys and brain
Abstract
The results of experimental investigations of the effects of Laennec on chronic iron overload. Long-term (2 weeks) application of iron sulfate or iron polymaltose complex composition caused chronic iron overload (hemosiderosis). The liver and kidneys is more pronounced when using iron sulfate and a few less - when using polymaltose complex. Laennec decreased the damage of hepatocytes (decreased ALT levels). According to histological analysis application Laennec reduced iron deposition in the liver and kidneys and completely prevented the formation of iron deposits in the brain.
About the Authors
O. A. Nazarenko
FGBOU IN «Ivanovo State Medical Academy» Russian Ministry of Health
Russian Federation
Russian Federation
O. A. Gromova
FGBOU IN «Ivanovo State Medical Academy» Russian Ministry of Health
Russian Federation
Russian Federation
T. R. Grishina
FGBOU IN «Ivanovo State Medical Academy» Russian Ministry of Health
Russian Federation
Russian Federation
I. Yu. Torshin
FGBOU IN «Moscow Institute of Physics and Technology»
Russian Federation
Russian Federation
V. I. Demidov
FGBOU IN «Ivanovo State Medical Academy» Russian Ministry of Health
Russian Federation
Russian Federation
I. K. Tomilova
FGBOU IN «Ivanovo State Medical Academy» Russian Ministry of Health
Russian Federation
Russian Federation
E. L. Aleksakhina
FGBOU IN «Ivanovo State Medical Academy» Russian Ministry of Health
Russian Federation
Russian Federation
I. V. Gogoleva
FGBOU IN «Ivanovo State Medical Academy» Russian Ministry of Health
Russian Federation
Russian Federation
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Review
For citations:
Nazarenko O.A., Gromova O.A., Grishina T.R., Torshin I.Yu., Demidov V.I., Tomilova I.K., Aleksakhina E.L., Gogoleva I.V. Correction by Laennec of chronic iron overload liver, kidneys and brain. Pharmacokinetics and Pharmacodynamics. 2017;(2):39-44. (In Russ.)
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