Chemoreactome modeling the effects of anions of lithium salts ascorbate, nicotinate, hydroxybutyrate komenata and lithium carbonate
Abstract
The estimates of the neurophysiological, pharmacokinetic, hemodynamic and anti-inflammatory properties of ascorbate anion were obtained. In comparison with the control molecules (nicotinate, oxybutyrate, comenate, carbonate) ascorbate anion has characteristically higher affinity for serotonin, dopamine, benzodiazepine, adrenergic receptors. Higher affinity for human benzodiazepine receptor indicates possible anxiolytic effects of ascorbate. Ascorbate anion can be characterized by a strong antioxidant and anti-inflammatory effect caused by modulation of prostaglandin metabolism. Ascorbate anion can also exhibit anticoagulant, antihyperglycemic and antihyperlipidemic effects. Chemoreactome simulation results also indicated that carbonate anion has none of the aforementioned properties of ascorbate anion.
About the Authors
I. Yu. Torshin
Moscow Institute of Physics and Technology (State University)
Russian Federation
Russian Federation
I. S. Sardaryan
FSBI HPE «St. Petersburg State Pediatric Medical University» of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
O. A. Gromova
FSBI HPE «Ivanovo State Medical Academy» of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
V. A. Rastashansky
Moscow Institute of Physics and Technology (State University)
Russian Federation
Russian Federation
L. E. Fedotova
FSBI HPE «Ivanovo State Medical Academy» of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
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Review
For citations:
Torshin I.Yu., Sardaryan I.S., Gromova O.A., Rastashansky V.A., Fedotova L.E. Chemoreactome modeling the effects of anions of lithium salts ascorbate, nicotinate, hydroxybutyrate komenata and lithium carbonate. Pharmacokinetics and Pharmacodynamics. 2016;(3):47-57. (In Russ.)
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