Dimeric dipeptide mimetics of the nerve growth factor loops 3 and 4 are active in a model of ischemic stroke
Abstract
Pharmacological activity of dimeric dipeptide mimetics of the nerve growth factor loops 3 and 4, correspondingly GTS-115 and GK-2, was studied in a model of ischemic stroke, induced by transient middle cerebral artery occlusion in rats. The both compounds, at i.p. subchronic administration (0,5-1 mg/kg/day, 7 days, beginning at 4 hours after surgery), significantly reduced cerebral infarct volume as was estimated by morphometry of 2,3,5-triphenyltetrazolium chloride (TTC) -stained brain slices: GTS-115 by 25% and GK-2 by 35%. Mimetic of NGF loop 4 (GK-2), which is the most active compound, was selected for further development as a potential therapeutic agent.
About the Authors
P. Y. Povarnina
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
T. A. Gudasheva
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
S. B. Seredenin
FSBI «Zakusov Institute of Pharmacology»
Russian Federation
Russian Federation
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Review
For citations:
Povarnina P.Y., Gudasheva T.A., Seredenin S.B. Dimeric dipeptide mimetics of the nerve growth factor loops 3 and 4 are active in a model of ischemic stroke. Pharmacokinetics and Pharmacodynamics. 2016;(3):34-37. (In Russ.)
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