Pharmacokinetic comparative study of tropoxine metabolite in miscellaneous animal species and humans
Abstract
Results of pharmacokinetic study of tropoxine metabolite (tropinone oxime; M-1) in experimental animals (rats, rabbits) and humans after administration several doses of tropoxine. Comparative analysis of the pharmacokinetic parameters characterizing of the metabolite formation intensity, i.e. Cmax of metabolite M-1 in the blood plasma increased in series: rats>humans> rabbits. Elimination rate of M-1 was decreased in series: rats>rabbits>humans
About the Authors
V. P. Zherdev
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
G. B. Kolyvanov
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
A. A. Litvin
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
P. O. Bochkov
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
R. V. Shevchenko
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
O. G. Grybakina
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
T. S. Ganshina
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
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Review
For citations:
Zherdev V.P., Kolyvanov G.B., Litvin A.A., Bochkov P.O., Shevchenko R.V., Grybakina O.G., Ganshina T.S. Pharmacokinetic comparative study of tropoxine metabolite in miscellaneous animal species and humans. Pharmacokinetics and Pharmacodynamics. 2017;(2):30-34. (In Russ.)
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