Comparative analysis activation of post-receptor signal ways by dimeric dipeptide mimetiks of different loops of NGF
Abstract
On culture of hippocampal HT-22 cells line it is shown that dimeric dipeptide mimetiks of different Loops of NGF realize their action via specific neurotrophic TrkA-receptor and selective activate post-receptor intracellular signal ways. Mimetiks of 1th (GK-6 (10-6M)) and the 3rd Loops (GTS-115 ((10-6M)) evoke activation of two main signal cascades - PI3/Akt and MAP/Erk, while mimetic the 4th loop of NGF (GK-2 (10-8M)) only one - a PI3/Akt-way.
About the Authors
T. A. Antipova
FSBI «Zakusov Institute of PharmacoLogy»
Russian Federation
Russian Federation
I. O. Logvinov
FSBI «Zakusov Institute of PharmacoLogy»
Russian Federation
Russian Federation
S. V. Nikolaev
FSBI «Zakusov Institute of PharmacoLogy»
Russian Federation
Russian Federation
S. V. Kruglov
FSBI «Zakusov Institute of PharmacoLogy»
Russian Federation
Russian Federation
A. V. Tarasiuk
FSBI «Zakusov Institute of PharmacoLogy»
Russian Federation
Russian Federation
P. I. Antipov
FSBI «Zakusov Institute of PharmacoLogy»
Russian Federation
Russian Federation
T. A. Gudasheva
FSBI «Zakusov Institute of PharmacoLogy»
Russian Federation
Russian Federation
S. B. Seredenin
FSBI «Zakusov Institute of PharmacoLogy»
Russian Federation
Russian Federation
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Review
For citations:
Antipova T.A., Logvinov I.O., Nikolaev S.V., Kruglov S.V., Tarasiuk A.V., Antipov P.I., Gudasheva T.A., Seredenin S.B. Comparative analysis activation of post-receptor signal ways by dimeric dipeptide mimetiks of different loops of NGF. Pharmacokinetics and Pharmacodynamics. 2016;(2):14-17. (In Russ.)
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