Excretion of the drug glutaron - a new derivative of glutamic acid
Abstract
In the study of excretion of the drug was found that glutaron determined in urine for at least 72 hours of the study. Renal clearance is 123 ml/hour, extrarenal - 34.84 ml/hour by intravenous route of administration. Superiority over extrarenal and renal clearance correlates with earlier data on the distribution of glutaron in organs and tissues. The drug was determined in the organs responsible for elimination (liver, kidneys and lungs) at high concentrations.
About the Authors
L. A. Smirnova
Volgograd Medical University
Russian Federation
Russian Federation
E. A. Suchkov
Volgograd Medical University
Russian Federation
Russian Federation
A. F. Ryabukha
Volgograd Medical University
Russian Federation
Russian Federation
K. A. Kuznetsov
Volgograd Medical University
Russian Federation
Russian Federation
I. N. Tyurenkov
Volgograd Medical University
Russian Federation
Russian Federation
V. N. Perfilova
Volgograd Medical University
Russian Federation
Russian Federation
References
1. Белоусов Ю.Б. Клиническая фармакокинетика, Литтерра, Москва, 2005
2. Каркищенко Н.Н., Хоронько В.В., Сергеева С.А., Каркищенко В.Н. Фармакокинетика, Феникс, Ростов-на-Дону, 2001
3. Руководство по экспериментальному (доклиническому) изучению новых фармакологических веществ, Р.У. Хабриева (ред.) Москва, 2005
4. Тюренков И.Н., Багметова В.В., Чернышева Ю.В. // Вестник Волг. гос. мед. универ. - 2012. - № 3 (43). - С. 21-24.5.
5. Тюренков И.Н., Перфилова В.Н., Смирнова Л.А. и др. // Хим-фарм. журнал.-2010.- Т.44, №12.- С.68-70.
6. Тюренков И.Н., Перфилова В.Н., Смирнова Л.А. и др. //Хим-фарм. журнал.-2013.-Т.47, №3.-С.55-56.
Review
For citations:
Smirnova L.A., Suchkov E.A., Ryabukha A.F., Kuznetsov K.A., Tyurenkov I.N., Perfilova V.N. Excretion of the drug glutaron - a new derivative of glutamic acid. Pharmacokinetics and Pharmacodynamics. 2014;(1):50-51. (In Russ.)
Views:
506
Email this article 