Determination of the safety of glycopeptides lactic acid bacteria in laboratory animals
https://doi.org/10.24411/2587-7836-2019-10049
Abstract
The study of acute toxicity and allergenity glycopeptides lactic acid bacteria in mice and rabbits. At the present level of physical, chemical and biological pollution of the environment, domestic and farm animals in no less, if not more than people, suffer from secondary induced immunodeficiency - an imbalance in the normal functioning of the immune system. This leads to a significant reduction in the overall resistance of the animal to various diseases of a viral and bacterial nature. The normal functioning of the animal's immune system can be restored with the help of immunomodulators, the active principle of which is the glycopeptide synthesized from natural components - a universal structural fragment of the lactic acid bacteria cell membrane that interacts with the immune system of the animal organism.
Conflicts of Interest Disclosure:
The authors declares that there is no conflict of interest.
Article info:
Date submitted: 06.04.2020
All authors have read and approved the final manuscript.
Peer review info:
"Pharmacokinetics and Pharmacodynamics" thanks the anonymous reviewer(s) for their contribution to the peer review of this work.
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About the Authors
O. V. Sofronova
All-Russian Research Institute of Physiology, Biochemistry and Nutrition of animals - branch of Federal state budgetary scientific institution "Federal Research Center Livestock - AUIAB Academician LK Ernst"
Russian Federation
L. L. Polyakova
All-Russian Research Institute of Physiology, Biochemistry and Nutrition of animals - branch of Federal state budgetary scientific institution "Federal Research Center Livestock - AUIAB Academician LK Ernst"
Russian Federation
A. N. Ovcharova
All-Russian Research Institute of Physiology, Biochemistry and Nutrition of animals - branch of Federal state budgetary scientific institution "Federal Research Center Livestock - AUIAB Academician LK Ernst"
Russian Federation
For citations:
Sofronova O.V.,
Polyakova L.L.,
Ovcharova A.N.
Determination of the safety of glycopeptides lactic acid bacteria in laboratory animals. Pharmacokinetics and Pharmacodynamics. 2019;(2):59-63.
(In Russ.)
https://doi.org/10.24411/2587-7836-2019-10049
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