Technological aspects of the production of orodispersible tablets
S. V. Tishkov,
D. D. Vuynovich,
V. B. Markeev,
V. L. Mistyukov,
M. S. Sergeeva,
E. V. Blynskaya,
V. L. Dorofeev https://doi.org/10.37489/2587-7836-2026-2-90-100
EDN: FPTZJQ
Abstract
Development of the composition and manufacturing technology of orodispersible tablets (ODT) is becoming increasingly promising due to their applicability in pediatric and geriatric practice, including for patients with dysphagia or in the absence of water. Furthermore, the ability to ensure the absorption of the active pharmaceutical ingredient (API) through the oral mucosa, bypassing the gastrointestinal tract, opens up new opportunities for preventing the adverse effects of the acidic gastric environment and first-pass metabolism on the API. This article provides an overview of the principal methods and technologies for the production of ODT, featuring examples of the most advanced technologies, as well as the excipients employed.
Keywords
tablets dispersible in the oral cavity,
orally disintegrating tablets ODT,
ODT production technologies,
sublimation process
Supporting agencies: This work was conducted under the government contract of the Ministry of Science and Higher Education of the Russian Federation (FGFG -2025-0010)
About the Authors
S. V. Tishkov
Federal research center for innovator and emerging biomedical and pharmaceutical technologies
Russian Federation
Russian Federation
Sergey V. Tishkov – PhD, Cand. Sci. (Pharm.), Leading Researcher of the Laboratory of Drug Technology of the Department of Quality and Technology
of Drugs
Moscow
D. D. Vuynovich
Federal research center for innovator and emerging biomedical and pharmaceutical technologies
Russian Federation
Russian Federation
Danilo D. Vuynovich – Graduate Student, Leading Engineer of the Laboratory of Drug Technology of the Department of Quality and Technology of Drugs
Moscow
V. B. Markeev
Federal research center for innovator and emerging biomedical and pharmaceutical technologies
Russian Federation
Russian Federation
Vladimir B. Markeev – PhD, Cand. Sci. (Pharm.), Senior Researcher of the Laboratory of Drug Technology of the Department of Quality and Technology
of Drugs
Moscow
V. L. Mistyukov
Federal research center for innovator and emerging biomedical and pharmaceutical technologies
Russian Federation
Russian Federation
Vladislav L. Mistyukov – Graduate Student, Leading Engineer of the Laboratory of Drug Technology of the Department of Quality and Technology of Drugs
Moscow
M. S. Sergeeva
Federal research center for innovator and emerging biomedical and pharmaceutical technologies
Russian Federation
Russian Federation
Mariya S. Sergeeva – PhD, Cand. Sci. (Pharm.), Head of the Laboratory of Drug Standardization and Quality control of the Department of Quality and Technology of Drugs
Moscow
E. V. Blynskaya
Federal research center for innovator and emerging biomedical and pharmaceutical technologies
Russian Federation
Russian Federation
Evgenia V. Blynskaya – PhD, Dr. Sci. (Pharm.), Head of the Laboratory of Drug Technology of the Department of Quality and Technology of Drugs
Moscow
V. L. Dorofeev
Federal research center for innovator and emerging biomedical and pharmaceutical technologies
Russian Federation
Russian Federation
Vladimir L. Dorofeev – PhD, Dr. Sci. (Pharm), Professor, Acting General Director
Moscow
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Review
For citations:
Tishkov S.V., Vuynovich D.D., Markeev V.B., Mistyukov V.L., Sergeeva M.S., Blynskaya E.V., Dorofeev V.L. Technological aspects of the production of orodispersible tablets. Pharmacokinetics and Pharmacodynamics. 2026;(2):90-100. (In Russ.) https://doi.org/10.37489/2587-7836-2026-2-90-100. EDN: FPTZJQ
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