Development of an alternative zebrafish (Danio rerio) model for identifying the adaptogenic effects of pharmacological compounds
https://doi.org/10.37489/2587-7836-2025-4-42-45
Abstract
Reliable primary screening studies using biomodels, which enable rapid and cost-effective identification of the effects of potential medicinal substances, are a crucial step in preclinical research. Therefore, the development of new alternative biological models, taking into account bioethical requirements, is a pressing issue in modern pharmacology. This article presents data on the creation of an alternative zebrafish model for identifying the adaptogenic effects of biologically active substances. Pharmacological validation of the resulting model is conducted. The feasibility of using the resulting model for primary screening of compounds with potential adaptogenic activity is demonstrated.
About the Author
A. O. Revyakin
Russian State Agrarian University — Moscow Timiryazev Agricultural Academy
Russian Federation
Russian Federation
Artem O. Revyakin — PhD, Cand. Sci. (Biology), Associate Professor, Chair of Animal Science
Moscow
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Review
For citations:
Revyakin A.O. Development of an alternative zebrafish (Danio rerio) model for identifying the adaptogenic effects of pharmacological compounds. Pharmacokinetics and Pharmacodynamics. 2025;(4):42-45. (In Russ.) https://doi.org/10.37489/2587-7836-2025-4-42-45
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