Evaluation of ATX rubricator drugs by chemoreactome screening method for prevention of magnesium and pyridoxine deficiencies

Relevance. Medicines can cause the body to lose magnesium and pyridoxine (vitamin B₆), which leads to the formation of side effects and worsens the course of the underlying disease.

Objective. Evaluation of the antimicronutrient effect of all drugs registered in the ATX rubricator using chemoreactome screening.

Materials and methods. Using methods of topological data analysis and labeled graph analysis, a systematic computer analysis of databases (SIDER, FAERS, PubChem, HMDB) was performed, algorithms for predicting magnesium-excreting and pyridoxine-excreting properties of drugs were developed, followed by screening of 2527 ATC drugs.

Results. The accuracy of the algorithms in cross-validation was 94–98 % for magnesium deficiency and 88 % for vitamin B₆ deficiency. On average, each drug accounts for 8.5±6.5 antimicronutrient effects. Only 4 % of drugs did not show a negative effect on micronutrient metabolism. Pyridoxine deficiency is caused by 1701 drugs (68 % of ATC), magnesium deficiency — by 1064 drugs (42 %). The most negative impact on the homeostasis of both micronutrients is exerted by antibiotics (J01), psychotropic drugs (N05, N06), antineoplastic agents (L01), hormones (G03), diuretics (C03), analgesics (N02) and antiinflammatory drugs (M01).

Conclusion. The results of chemoreactome screening will allow us to reasonably recommend accompanying various pharmacotherapy with drugs based on pyridoxine and organic magnesium salts.

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