GK-2 — dipeptide mimetic of 4th loop NGF increases the level of BDNF and is active in the cell model of Parkinson's disease
https://doi.org/10.37489/2587-7836-2025-3-3-8
EDN: ZRAIYQ
Abstract
NGF at a concentration of 100 ng / ml when added 24 hours before 6-OHDA and after damage completely prevented the development of the damaging effect of neurotoxin. Dipeptide GK-2 at a concentration of 10−5 M, similar to NGF, showed a protective effect on the cellular model of Parkinson's disease. According to the Western blot analysis NGF increased the level of BDNF in the HT-22 cells 1.6 times compared to the control, and dipeptide GK-2 at a concentration of 10−8 M — 1.4 times compared to the control.
About the Authors
Т. A. Antipova
Federal research center for innovator and emerging biomedical and pharmaceutical technologies
Russian Federation
Russian Federation
Tatyana A. Antipova — PhD, Cand. Sci. (Biology), Leading researcher, Molecular pharmacology laboratory
Moscow
S. V. Nikolaev
Federal research center for innovator and emerging biomedical and pharmaceutical technologies
Russian Federation
Russian Federation
Sergey V. Nikolaev — Research Scientist Molecular pharmacology laboratory
Moscow
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Review
For citations:
Antipova Т.A., Nikolaev S.V. GK-2 — dipeptide mimetic of 4th loop NGF increases the level of BDNF and is active in the cell model of Parkinson's disease. Pharmacokinetics and Pharmacodynamics. 2025;(3):3-8. (In Russ.) https://doi.org/10.37489/2587-7836-2025-3-3-8. EDN: ZRAIYQ
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