Experimental models of aging
https://doi.org/10.37489/2587-7836-2024-4-17-21
EDN: VMQTRD
Abstract
Aging is the result of combined changes in many biological processes that are associated with impaired functional status in humans and increase the risk of chronic pathologies. Since there are a number of insurmountable difficulties in conducting clinical studies on humans, it is necessary to resort to experimental modeling of key signs of aging and associated pathologies.
However, all the used models of aging are far from perfect, since there are a number of factors that do not allow a full comparison of the mechanisms of the aging process in humans and animals. This article presents the main experimental models of aging and determines their advantages and disadvantages in the context of potential studies.
About the Authors
A. A. Garanin
Ivanovo State Medical University of MOH of Russia
Russian Federation
Russian Federation
Alexey A. Garanin – Assistant Professor, Chair of Pharmacology
Ivanovo
O. A. Gromova
Ivanovo State Medical University of MOH of Russia; Federal Research Center «Computer Science and Control»
Russian Federation
Russian Federation
Olga A. Gromova – Dr. Sci. (Med.), Professor of the Department of Pharmacology
Ivanovo;
Moscow
T. E. Bogacheva
Ivanovo State Medical University of MOH of Russia
Russian Federation
Russian Federation
Tatiana E. Bogacheva – PhD, Cand. Sci. (Med.), Associate Professor of the Department of Pharmacology
Ivanovo
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Review
For citations:
Garanin A.A., Gromova O.A., Bogacheva T.E. Experimental models of aging. Pharmacokinetics and Pharmacodynamics. 2024;(4):17-21. (In Russ.) https://doi.org/10.37489/2587-7836-2024-4-17-21. EDN: VMQTRD
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