Preview

Pharmacokinetics and Pharmacodynamics

Advanced search

Application of variance analysis in experimental pharmacology

https://doi.org/10.37489/2587-7836-2023-1-3-23

Abstract

The article discusses various types of variance analysis: one-factor, two-factor, repeated measurements, including detailed analysis of variance categorical data. The criteria of multiple comparisons are described: according to Bonferroni, according to Newman-Kales, according to Dunnet, according to Scheffe. All the methods considered are accompanied by examples of analysis of pharmacological data.

About the Author

I. B. Tsorin
FSBI “Zakusov Institute of Pharmacology”
Russian Federation

Tsorin Iosif B., Dr. Sci. (Biology), Leading researcher of laboratory of pharmacological screening

Moscow



References

1. Glantz St.A. Primer of biostatistics. Fouth Edition. McGraw-Hill: Health Professions Division. New York; 1994. (In Russ).

2. Fisher R.A. Statistical metthods for research workers – Oliver&boyd, Edinburgh, 1925. 149 p.

3. Scheffe H. The analysis of variance. New York: John Willey&Sons Inc. 1958. (In Russ).

4. Lakin GF. Biometriya: Study guide for biol. spec. universities. 4th ed., reprint. and add. Moscow: “Vyshaya shcola”; 1990. (In Russ).

5. Plohinskij NA. Biometriya. Izdanie 2-e. Moscow: «Izdatel'stvo Moskovskogo Universiteta»; 1970. (In Russ).

6. Kulikov EI. Prikladnoj statisticheskij analiz : uchebnoe posobie dlya studentov vysshih uchebnyh zavedenij / Kulikov EI. 2nd ed., reprint. and additional. M.: “Goryachaea liniyaTelecom”; 2008. (In Russ).

7. Kobzar AI. Prikladnaya matematicheskaya statistika. Dlya inzhenerov i nauchnyh rabotnikov. Moscow: Fizmatlit; 2006. (In Russ).

8. Hochberg Y., Benjamini Y. More powerful procedures for multiple significance testing. Stat Med. 1990 Jul;9(7):811–818. DOI: 10.1002/sim.4780090710.

9. Benjamini Y., Hochberg Y. Controling the false discovery rate: practical and powerful approach to multiple testing. J.R. Statist. Soc. B. 1995; 57(1):289–300.

10. Sergienko VI, Bondareva IB. Matematicheskaya statistika v klinicheskih issledovaniyah 2nd ed., reprint. and add. Moscow: GEOTAR-Medi. 2006. (In Russ).

11. Dannet C.W. New tables multiple comparisons with control. Biometrics. 1964;20:482–491.

12. Lang TA, Sesik M. Prikladnoj statisticheskij analiz : uchebnoe posobie dlya studentov vysshih uchebnyh zavedenij / Kulikov EI. 2nd ed., reprint. and additional. Moscow: “Goryachaea liniya-Telecom”; 2008. (In Russ).

13. Tsorin IB. Statistical processing of pharmacological experiments results measured in ordinal and quantitative scales, if it is impossible to analyze using parametric methods. Farmakokinetika i farmakodinamika. 2020;(3):3–24. (In Russ). DOI: 10.37489/2587-7836-2020-3-3-24.

14. Kramarenko SS. Dispersionnyj analiz kachestvennyh priznakov. Krymskij malakologicheskij sajt. 2006. URL: http://www.malacology.narod.ru/download/kramarenko_2006_disp.html


Review

For citations:


Tsorin I.B. Application of variance analysis in experimental pharmacology. Pharmacokinetics and Pharmacodynamics. 2023;(1):3-23. (In Russ.) https://doi.org/10.37489/2587-7836-2023-1-3-23

Views: 427


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2587-7836 (Print)
ISSN 2686-8830 (Online)