The effect of fabomotizole on blood microcirculation in intact and ischemic myocardium
https://doi.org/10.37489/2587-7836-2022-2-31-35
Abstract
The investigation purpose was to study the effect of fabomotizole on blood microcirculation in intact and ischemic myocardium in conditions of acute ischemia of the heart muscle. The experiments were carried out on anesthetized (urethane, 1300 mg/kg, i.p.) white mongrel male rats weighing 220–250 g. Acute myocardial ischemia was caused by occlusion of the left coronary artery. Blood microcirculation was evaluated by laser Doppler flowmetry using a computerized laser analyzer "LAKK-OP2". It was found that fabomotizole (15 mg/kg, i.v.) in an intact heart does not affect blood microcirculation. Immediately after coronary artery ligation in the myocardial ischemia zone, microcirculation decreases sharply (by about 30 %, p = 0.0106) and practically does not change in the conditionally intact myocardium. Fabomotizole, administered 5 minutes before occlusion of the coronary artery, prevented a decrease in microcirculation in the ischemiс zone of the myocardium. The ability of fabomotizole in conditions of acute myocardial ischemia to prevent a decrease in the level of microcirculation in the ischemic zone may contribute to the anti-ischemic activity of the drug.
About the Authors
I. B. Tsorin
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
Tsorin Iosif B., Dr. Sci. Biological, Leading researcher of laboratory of pharmacological screening. SPIN code: 4015-3025
Moscow
S. A. Simonenko
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
Simonenko Sophia A., Laboratory assistant of laboratory of pharmacological screening
Moscow
M. B. Vititnova
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
Vititnova Marina B., PhD Biological Sci., Senior researcher scientist of laboratory of pharmacological screening. SPIN code: 1901-8919
Moscow
S. A. Kryzhanovskiy
FSBI “Zakusov Institute of Pharmacology”
Russian Federation
Russian Federation
Kryzhanovskiy Sergey A., Dr. Sci. (Med.), Head of laboratory of pharmacological screening. SPIN code: 6596-4865
Moscow
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Review
For citations:
Tsorin I.B., Simonenko S.A., Vititnova M.B., Kryzhanovskiy S.A. The effect of fabomotizole on blood microcirculation in intact and ischemic myocardium. Pharmacokinetics and Pharmacodynamics. 2022;(2):31-35. (In Russ.) https://doi.org/10.37489/2587-7836-2022-2-31-35
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